Ameliorative effect of edible Halopteris scoparia against cadmium-induced reproductive toxicity in male mice: A biochemical and histopathologic study.

Autor: Güner Ö; Department of Nursing, Sinop University School of Health, Sinop, Turkey., Güner A; Department of Biology, Faculty of Arts and Sciences, Giresun University, Giresun, Turkey., Yavaşoğlu A; Department of Histology and Embryology, Faculty of Medicine, Ege University, İzmir, Turkey., Karabay Yavaşoğlu NÜ; Department of Biology, Faculty of Science, Ege University, İzmir, Turkey., Kavlak O; Department of Gynecologic and Obstetric Nursing, Faculty of Nursing, Ege University, Izmir, Turkey.
Jazyk: angličtina
Zdroj: Andrologia [Andrologia] 2020 Jul; Vol. 52 (6), pp. e13591. Date of Electronic Publication: 2020 Apr 22.
DOI: 10.1111/and.13591
Abstrakt: Cadmium (Cd) is a toxic metal affecting the reproductive system. Halopteris scoparia (brown algae) is generally consumed as a salad in the Far East countries. This study was conducted to compare and determine the possible protective effects of H. scoparia and vitamin E and C combination (VEC) against cadmium chloride (CdCl 2 )-induced reproductive toxicity. A total of 36 male mice were equally divided into as control, CdCl 2 (2 mg/kg), CdCl 2  + H. scoparia (900 mg/kg), CdCl 2  + VEC (200 mg/kg), H. scoparia alone and VEC alone groups. Blood and testis samples were taken for biochemical, histochemical and immunohistochemical analyses. H. scoparia was also examined for antioxidant activity (by DPPH assay) and mineral/trace element content (by ICP-MS method). CdCl 2 exposure caused a significant deterioration in body weight, sperm parameters (count, motility, viability and morphology) (p < .001), histopathology, immunoreactivity and testosterone levels. However, H. scoparia improved CdCl 2 -induced deterioration effects more successfully than VEC-treated group. The present study suggests that edible H. scoparia can be used as a natural protective agent against Cd-induced testicular damage by possibly enhancing essential element levels or increasing antioxidant defence system.
(© 2020 Blackwell Verlag GmbH.)
Databáze: MEDLINE
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