Weight Change 2 Years After Termination of the Intensive Lifestyle Intervention in the Look AHEAD Study.

Autor: Chao AM; Department of Biobehavioral Health Sciences, School of Nursing, University of Pennsylvania, Philadelphia, Pennsylvania, USA.; Department of Psychiatry, University of Pennsylvania, Philadelphia, Pennsylvania, USA., Wadden TA; Department of Psychiatry, University of Pennsylvania, Philadelphia, Pennsylvania, USA., Berkowitz RI; Department of Psychiatry, University of Pennsylvania, Philadelphia, Pennsylvania, USA., Blackburn G; Division of Nutrition, Beth Israel Deaconess Medical Center, Boston, Massachusetts, USA., Bolin P; Southwestern American Indian Center, National Institute of Diabetes and Digestive and Kidney Diseases and St. Joseph's Hospital and Medical Center, Phoenix, Arizona, USA., Clark JM; Division of General Internal Medicine, Johns Hopkins University, Baltimore, Maryland, USA., Coday M; Departments of Preventive Medicine and Psychiatry, The University of Tennessee Health Science Center, Memphis, Tennessee, USA., Curtis JM; Southwestern American Indian Center, National Institute of Diabetes and Digestive and Kidney Diseases and St. Joseph's Hospital and Medical Center, Phoenix, Arizona, USA., Delahanty LM; Department of Medicine, Massachusetts General Hospital, Boston, Massachusetts, USA., Dutton GR; Division of Preventive Medicine, Department of Medicine, University of Alabama at Birmingham, Birmingham, Alabama, USA., Evans M; Division of Digestive Diseases and Nutrition, National Institute of Diabetes and Digestive and Kidney Diseases, Bethesda, Maryland, USA., Ewing LJ; Department of Psychiatry, University of Pittsburgh, Pittsburgh, Pennsylvania, USA., Foreyt JP; Department of Medicine, Baylor College of Medicine, Houston, Texas, USA., Gay LJ; Department of Psychiatry, The Miriam Hospital, Brown Medical School, Providence, Rhode Island, USA., Gregg EW; Division of Diabetes Translation, Centers for Disease Control and Prevention, Atlanta, Georgia, USA., Hazuda HP; Department of Medicine, University of Texas Health Science Center at San Antonio, San Antonio, Texas, USA., Hill JO; Anschutz Health and Wellness Center, University of Colorado Anschutz Medical Campus, Aurora, Colorado, USA., Horton ES; Department of Integrative Physiology and Metabolism, Joslin Diabetes Center, Boston, Massachusetts, USA., Houston DK; Department of Internal Medicine - Geriatrics, Wake Forest University, Winston-Salem, North Carolina, USA., Jakicic JM; Department of Psychiatry, University of Pittsburgh, Pittsburgh, Pennsylvania, USA., Jeffery RW; Divisions of Epidemiology and Community Health, University of Minnesota, Minneapolis, Minnesota, USA., Johnson KC; Departments of Preventive Medicine and Psychiatry, The University of Tennessee Health Science Center, Memphis, Tennessee, USA., Kahn SE; Division of Metabolism, Endocrinology and Nutrition, US Department of Veterans Affairs Puget Sound Health Care System, University of Washington, Seattle, Washington, USA., Knowler WC; Southwestern American Indian Center, National Institute of Diabetes and Digestive and Kidney Diseases and St. Joseph's Hospital and Medical Center, Phoenix, Arizona, USA., Kure A; Division of Metabolism, Endocrinology and Nutrition, US Department of Veterans Affairs Puget Sound Health Care System, University of Washington, Seattle, Washington, USA., Michalski KL; Division of General Internal Medicine, Johns Hopkins University, Baltimore, Maryland, USA., Montez MG; Department of Medicine, University of Texas Health Science Center at San Antonio, San Antonio, Texas, USA., Neiberg RH; Department of Internal Medicine - Geriatrics, Wake Forest University, Winston-Salem, North Carolina, USA., Patricio J; Department of Medicine, St. Luke's Roosevelt Hospital Center, Columbia University, New York, New York, USA., Peters A; Division of Endocrinology, University of Southern California, Los Angeles, California, USA., Pi-Sunyer X; Department of Medicine, St. Luke's Roosevelt Hospital Center, Columbia University, New York, New York, USA., Pownall H; Department of Medicine, Baylor College of Medicine, Houston, Texas, USA., Reboussin D; Department of Internal Medicine - Geriatrics, Wake Forest University, Winston-Salem, North Carolina, USA., Redmon B; Divisions of Epidemiology and Community Health, University of Minnesota, Minneapolis, Minnesota, USA., Rejeski WJ; Department of Internal Medicine - Geriatrics, Wake Forest University, Winston-Salem, North Carolina, USA., Steinburg H; Departments of Preventive Medicine and Psychiatry, The University of Tennessee Health Science Center, Memphis, Tennessee, USA., Walker M; Division of Endocrinology, University of Southern California, Los Angeles, California, USA., Williamson DA; Pennington Biomedical Research Center, Baton Rouge, Louisiana, USA., Wing RR; Department of Psychiatry, The Miriam Hospital, Brown Medical School, Providence, Rhode Island, USA., Wyatt H; Anschutz Health and Wellness Center, University of Colorado Anschutz Medical Campus, Aurora, Colorado, USA., Yanovski SZ; Division of Digestive Diseases and Nutrition, National Institute of Diabetes and Digestive and Kidney Diseases, Bethesda, Maryland, USA., Zhang P; Division of Diabetes Translation, Centers for Disease Control and Prevention, Atlanta, Georgia, USA.
Jazyk: angličtina
Zdroj: Obesity (Silver Spring, Md.) [Obesity (Silver Spring)] 2020 May; Vol. 28 (5), pp. 893-901.
DOI: 10.1002/oby.22769
Abstrakt: Objective: This study evaluated weight changes after cessation of the 10-year intensive lifestyle intervention (ILI) in the Look AHEAD (Action for Health in Diabetes) study. It was hypothesized that ILI participants would be more likely to gain weight during the 2-year observational period following termination of weight-loss-maintenance counseling than would participants in the diabetes support and education (DSE) control group.
Methods: Look AHEAD was a randomized controlled trial that compared the effects of ILI and DSE on cardiovascular morbidity and mortality in participants with overweight/obesity and type 2 diabetes. Look AHEAD was converted to an observational study in September 2012.
Results: Two years after the end of the intervention (EOI), ILI and DSE participants lost a mean  (SE) of 1.2  (0.2) kg and 1.8  (0.2) kg, respectively (P = 0.003). In addition, 31% of ILI and 23.9% of DSE participants gained ≥ 2% (P < 0.001) of EOI weight, whereas 36.3% and 45.9% of the respective groups lost ≥ 2% of EOI weight (P = 0.001). Two years after the EOI, ILI participants reported greater use of weight-control behaviors than DSE participants.
Conclusions: Both groups lost weight during the 2-year follow-up period, but more ILI than DSE participants gained ≥ 2% of EOI weight. Further understanding is needed of factors that affected long-term weight change in both groups.
(© 2020 The Obesity Society.)
Databáze: MEDLINE
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