Association of Prenatal Alcohol Exposure and Offspring Depression: A Negative Control Analysis of Maternal and Partner Consumption.

Autor: Easey KE; From the, UK Centre for Tobacco and Alcohol Studies, (KEE, MRM), School of Psychological Science, University of Bristol, Bristol, UK.; MRC Integrative Epidemiology Unit, (KEE, NJT, MRM), University of Bristol, Bristol, UK.; Bristol Medical School, (KEE, NJT), University of Bristol, Bristol, UK., Timpson NJ; MRC Integrative Epidemiology Unit, (KEE, NJT, MRM), University of Bristol, Bristol, UK.; Bristol Medical School, (KEE, NJT), University of Bristol, Bristol, UK., Munafò MR; From the, UK Centre for Tobacco and Alcohol Studies, (KEE, MRM), School of Psychological Science, University of Bristol, Bristol, UK.; MRC Integrative Epidemiology Unit, (KEE, NJT, MRM), University of Bristol, Bristol, UK.
Jazyk: angličtina
Zdroj: Alcoholism, clinical and experimental research [Alcohol Clin Exp Res] 2020 May; Vol. 44 (5), pp. 1132-1140. Date of Electronic Publication: 2020 Apr 21.
DOI: 10.1111/acer.14324
Abstrakt: Background: Previous research has suggested that intrauterine alcohol exposure is associated with a variety of adverse outcomes in offspring. However, few studies have investigated its association with offspring internalizing disorders in late adolescence.
Methods: Using data from the Avon Longitudinal Study of Parents and Children (ALSPAC), we investigated the associations of maternal drinking in pregnancy with offspring depression at age 18 and 24 (n = 13,480). We also examined partner drinking as a negative control for intrauterine exposure for comparison.
Results: Offspring of mothers that consumed any alcohol at 18 weeks gestation were at increased risk of having a diagnosis of depression (fully adjusted model: OR 1.17, 95% CI 1.02 to 1.34), but there was no clear evidence of association between partners' alcohol consumption at 18 weeks gestation during pregnancy and increased risk of offspring depression (fully adjusted model: OR 0.87, 95% CI 0.74 to 1.01). Postestimation tests found a positive difference between the association of maternal and partner alcohol use on offspring depression, showing a stronger association for maternal compared with partner alcohol use (OR 1.41, CI 1.07 to 1.84).
Conclusions: Maternal drinking in pregnancy was associated with increased risk of offspring depression at age 18. Residual confounding may explain this association, but the negative control comparison of paternal drinking provides some evidence that it may be causal, and this warrants further investigation.
(© 2020 The Authors. Alcoholism: Clinical & Experimental Research published by Wiley Periodicals LLC on behalf of Research Society on Alcoholism.)
Databáze: MEDLINE
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