Indirect voltammetric determination of thiomersal in influenza vaccine using photo-degradation and graphene quantum dots modified glassy carbon electrode.

Autor: Pedrozo-Penafiel MJ; Chemistry Department, Pontifícia Universidade Católica do Rio de Janeiro (PUC-Rio), Rio de Janeiro-RJ, Brazil., Miranda-Andrades JR; Chemistry Department, Pontifícia Universidade Católica do Rio de Janeiro (PUC-Rio), Rio de Janeiro-RJ, Brazil., Gutierrez-Beleño LM; Chemistry Department, Pontifícia Universidade Católica do Rio de Janeiro (PUC-Rio), Rio de Janeiro-RJ, Brazil., Larrudé DG; MackGraphe, Graphene and Nanomaterial Research Center, Mackenzie Presbyterian University, São Paulo, Brazil., Aucelio RQ; Chemistry Department, Pontifícia Universidade Católica do Rio de Janeiro (PUC-Rio), Rio de Janeiro-RJ, Brazil. Electronic address: aucelior@puc-rio.br.
Jazyk: angličtina
Zdroj: Talanta [Talanta] 2020 Aug 01; Vol. 215, pp. 120938. Date of Electronic Publication: 2020 Mar 19.
DOI: 10.1016/j.talanta.2020.120938
Abstrakt: Thiomersal is an organomercury derivative that degrades producing thiosalicylic acid, dithiobenzoic acid and ethylmercury. It is widely used in topical pharmaceutical preparations and as preservative in vaccines and cosmetics. In this work, an electro-analytical method for thiomersal was developed using graphene quantum dots (GQDs) as a surface modifier of a glassy carbon electrode. The method rely on using square-wave voltammetry and exploring the synergistic effect between GQDs, visible radiation and the applied potential in producing very intense Hg oxidation peak during the anodic scan. A linear voltammetric response was obtained for the analyte in the concentration range from 3.0 μmol L -1 (1.2 μg mL -1 ) to 32 μmol L -1 (12 μg mL -1 ), with a detection limit of 0.9 μmol L -1 (0.34 μg mL -1 ). The proposed method was successfully applied for thiomersal determination in influenza vaccine.
Competing Interests: Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.
(Copyright © 2020 Elsevier B.V. All rights reserved.)
Databáze: MEDLINE
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