Continuous-Flow Accelerated Sulfation of Heparan Sulfate Intermediates.

Autor:	Anand S; Indian Institute of Science Education and Research, Dr. Homi Bhabha Road, Pune-411 008, India., Mardhekar S; Indian Institute of Science Education and Research, Dr. Homi Bhabha Road, Pune-411 008, India., Raigawali R; Indian Institute of Science Education and Research, Dr. Homi Bhabha Road, Pune-411 008, India., Mohanta N; Indian Institute of Science Education and Research, Dr. Homi Bhabha Road, Pune-411 008, India., Jain P; Indian Institute of Science Education and Research, Dr. Homi Bhabha Road, Pune-411 008, India., D Shanthamurthy C; Indian Institute of Science Education and Research, Dr. Homi Bhabha Road, Pune-411 008, India., Gnanaprakasam B; Indian Institute of Science Education and Research, Dr. Homi Bhabha Road, Pune-411 008, India., Kikkeri R; Indian Institute of Science Education and Research, Dr. Homi Bhabha Road, Pune-411 008, India.
Jazyk:	angličtina
Zdroj:	Organic letters [Org Lett] 2020 May 01; Vol. 22 (9), pp. 3402-3406. Date of Electronic Publication: 2020 Apr 20.
DOI:	10.1021/acs.orglett.0c00878
Abstrakt:	We report for the first time a continuous-flow strategy to execute O -sulfation modification of heparan sulfate (HS) oligosaccharides. A systematic investigation of the influence of the flow parameters on the installation of the sulfate group on glucosamine monosaccharide can aid the development of a comprehensive, quick, and reliable strategy for O -sulfation of HS oligosaccharide precursors. Deprotection of the sulfated heparin intermediates led to the development of a comprehensive biologically inspired oligosaccharide library to understand the crucial structure-function relationship of HS.
Databáze:	MEDLINE
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