Efficacy of three disinfectant formulations and a hydrogen peroxide/silver fogging system on surfaces experimentally inoculated with meticillin-resistant Staphylococcus pseudintermedius.

Autor: Soohoo J; Department of Clinical Sciences, Colorado State University College of Veterinary Medicine and Biomedical Sciences, 300 West Drake Road, Fort Collins, CO, 80523, USA., Daniels JB; Department of Microbiology, Immunology and Pathology, Colorado State University College of Veterinary Medicine and Biomedical Sciences, 300 West Drake Road, Fort Collins, CO, 80523, USA., Brault SA; Department of Clinical Sciences, Colorado State University College of Veterinary Medicine and Biomedical Sciences, 300 West Drake Road, Fort Collins, CO, 80523, USA., Rosychuk RAW; Department of Clinical Sciences, Colorado State University College of Veterinary Medicine and Biomedical Sciences, 300 West Drake Road, Fort Collins, CO, 80523, USA., Schissler JR; Department of Clinical Sciences, Colorado State University College of Veterinary Medicine and Biomedical Sciences, 300 West Drake Road, Fort Collins, CO, 80523, USA.
Jazyk: angličtina
Zdroj: Veterinary dermatology [Vet Dermatol] 2020 Oct; Vol. 31 (5), pp. 350-e91. Date of Electronic Publication: 2020 Jun 04.
DOI: 10.1111/vde.12858
Abstrakt: Background: Effective environmental disinfection is necessary to prevent nosocomial infections from meticillin-resistant Staphylococcus pseudintermedius (MRSP). However, there are currently no commercial disinfectant sprays or fogging systems with label claims against MRSP.
Hypothesis/objectives: To evaluate the efficacy of a quaternary ammonium product (QAC), an accelerated hydrogen peroxide product (AHP), a hydrogen peroxide and silver product (HAL), and a hydrogen peroxide and silver fogging system (FOG) against MRSP.
Methods and Materials: Sterile plastic surfaces inoculated with MRSP were treated with 200 µL of QAC, AHP or HAL for the recommended contact times. For FOG, inoculated samples were placed in eight positions within a sealed room before fogging for the recommended contact time. Post-treatment bacterial counts were compared to untreated positive controls. Sterile uninoculated surfaces served as negative controls.
Results: Least-squares mean reduction (log 10 ) in colony forming units (cfu) was 3.55 log 10 for QAC (P < 0.0001), 3.60 log 10 for AHP (P < 0.0001), 1.66 log 10 for HAL (P < 0.0001) and 0.32 log 10 for FOG (P = 0.004). QAC, AHP and HAL reduced MRSP cfu by 99.97%, 99.98% and 97.81%, respectively. FOG reduced cfu by 52.14%.
Conclusions and Clinical Importance: QAC and AHP effectively disinfected surfaces inoculated with MRSP. Although HAL provided lower MRSP reduction, it may be considered clinically acceptable. FOG as a sole means of MRSP disinfection was not supported yet may have utility as an adjunctive disinfectant in clinical areas with bacterial densities lower than our experimental inoculum.
(© 2020 ESVD and ACVD.)
Databáze: MEDLINE
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