Molecular docking analysis of alkaloid compounds with beta-catenin towards the treatment of colon cancer.
| Autor: | Ponnulakshmi R; Central Research Laboratory, Meenakshi Academy of Higher Education and Research (Deemed to be University), Chennai-600 078, India., Vishnupriya V; Department of Biochemistry, Saveetha Dental College and Hospitals, Saveetha Institute of Medical and Technical Sciences, Saveetha University, Chennai - 600 077, India., Mohan SK; Department of Biochemistry, Panimalar Medical College Hospital and Research Institute, Varadharajapuram, Poonamallee, Chennai-600 123, Chennai, Tamil Nadu, India., Abilasha S; Department of Anatomy, Asan Memorial Dental College and Hospital, Asan Nagar, Chengalpattu, Tamil Nadu, India., Ramajayam G; Multi Disciplinary Research Unit, Madurai Medical College, TamilNadu, India., Vijayalakshmi P; DBT-BIF Centre, PG and Research Department of Biotechnology & Bioinformatics, Holy Cross College (autonomous), Trichy, Tamil Nadu, India., Rajalakshmi M; DBT-BIF Centre, PG and Research Department of Biotechnology & Bioinformatics, Holy Cross College (autonomous), Trichy, Tamil Nadu, India., Selvaraj J; Department of Biochemistry, Saveetha Dental College and Hospitals, Saveetha Institute of Medical and Technical Sciences, Saveetha University, Chennai - 600 077, India. |
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| Jazyk: | angličtina |
| Zdroj: | Bioinformation [Bioinformation] 2020 Mar 31; Vol. 16 (3), pp. 283-287. Date of Electronic Publication: 2020 Mar 31 (Print Publication: 2020). |
| DOI: | 10.6026/97320630016283 |
| Abstrakt: | It is known that beta-catenin is associated with fibromatosis, sarcoma and mesenchymal tumor. Therefore, it is of interest to design an effective inhibtitor to the target protein beta-catenin. In this study, we report the molecular docking analysis of alkaloid compounds (aristolochicacid, cryptopleurine, demecolcine, fagaronine and thalicarpine) with beta-catenin for further consideration towards the design and development of potential inhintors for the treatmnet of colon cancer. (© 2020 Biomedical Informatics.) |
| Databáze: | MEDLINE |
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