Optimizing data processing to improve the reproducibility of single-subject functional magnetic resonance imaging.

Autor: Soltysik DA; Division of Biomedical Physics, Office of Science and Engineering Laboratories, Center for Devices and Radiological Health, Office of Medical Products and Tobacco, U.S. Food and Drug Administration, Silver Spring, MD, USA.
Jazyk: angličtina
Zdroj: Brain and behavior [Brain Behav] 2020 Jun; Vol. 10 (6), pp. e01617. Date of Electronic Publication: 2020 Apr 19.
DOI: 10.1002/brb3.1617
Abstrakt: Introduction: High reproducibility is critical for ensuring the confidence needed to use functional magnetic resonance imaging (fMRI) activation maps for presurgical planning.
Methods: In this study, the comparison of different motion correction methods, spatial smoothing methods, regression methods, and thresholding methods was performed to see whether specific data processing methods can be employed to improve the reproducibility of single-subject fMRI activation. Three test-retest metrics were used: the percent difference in activation volume (PDAV), the difference in the center of mass (DCM), and the Dice Similarity Coefficient (DSC).
Results: The PDAV was minimized when using little or no spatial smoothing and AMPLE thresholding. The DCM was minimized when using affine motion correction and little or no spatial smoothing. The DSC was improved when using affine motion correction and generous spatial smoothing. However, it is believed that the overlap metric may be unsuitable for testing fMRI reproducibility.
Conclusion: Processing methods to improve fMRI reproducibility were determined. Importantly, the processing methods needed to improve reproducibility were dependent on the fMRI activation metric of interest.
(Published 2020. This article is a U.S. Government work and is in the public domain in the USA. Brain and Behavior published by Wiley Periodicals LLC.)
Databáze: MEDLINE
Externí odkaz:
Nepřihlášeným uživatelům se plný text nezobrazuje