[The combined effect of genetic factors and attention deficit hyperactivity disorder on the development of dependence on synthetic cannabinoids].

Autor:	Gareeva AE; Bashkir State Medical University, Ufa, Russia; Institute of Biochemistry and Genetics, Ufa Federal Research Center of the Russian Academy of Sciences, Ufa, Russia., Sharafiev RR; Bashkir State Medical University, Ufa, Russia., Akhmetova EA; Bashkir State Medical University, Ufa, Russia., Nasibullin TR; Institute of Biochemistry and Genetics, Ufa Federal Research Center of the Russian Academy of Sciences, Ufa, Russia., Fakhurtdinova ZR; Bashkir State University, Ufa, Russia., Yuldashev VL; Bashkir State Medical University, Ufa, Russia., Asadullin AR; Bashkir State Medical University, Ufa, Russia.
Jazyk:	ruština
Zdroj:	Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova [Zh Nevrol Psikhiatr Im S S Korsakova] 2020; Vol. 120 (2), pp. 15-21.
DOI:	10.17116/jnevro202012002115
Abstrakt:	Aim: To develop a model of assessment of individual risk of dependence on synthetic cannabinoids based on genetic factors and diagnosis of attention deficit hyperactivity disorder (ADHD). Material and Methods: The study included 146 male adolescents using synthetic cannabinoids and 136 healthy people. The genetic study considered the combination of dependence on synthetic cannabinoids and ADHD. Six polymorphisms in the genes of dopaminergic and serotonergic systems were genotyped. Results and Conclusion: In general, the results of this work confirm the important role of the dopaminergic and serotonergic systems in the pathogenesis of substance use disorders, and the significance of changes in the nucleotide sequences of DRD2, SLC6A3, HTR2A genes in the development of dependence on synthetic cannabinoids with ADHD.
Databáze:	MEDLINE
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