[Diagnosis, prognosis and treatment of sinonasal carcinomas (excluding melanomas, sarcomas and lymphomas)].

Autor:	Thariat J; Baclesse Cancer Center, Radiation Oncology Department, Caen, France. Electronic address: jthariat@gmail.com., Moya Plana A; Gustave-Roussy Cancer Campus, Head and Neck Surgery Department, Villejuif, France., Vérillaud B; Lariboisière Hospital, Head and Neck Surgery Department, Paris, France., Vergez S; Toulouse University Hospital Center, Head and Neck Surgery Department, Toulouse, France., Régis-Ferrand F; Gustave-Roussy Cancer Campus, Head and Neck Oncology Department, Villejuif, France; HIA Begin, Medical Oncology Department, Saint-Mandé, France., Digue L; Pellegrin Hospital, Centre Michelet, Head and Neck Oncology Department, Bordeaux, France., Even C; Gustave-Roussy Cancer Campus, Head and Neck Oncology Department, Villejuif, France., Costes V; Montpellier Hospital, Department of Pathology, Montpellier, France., Baujat B; Tenon Hospital, Head and Neck Surgery Department, Paris, France., de Gabory L; Lariboisière Hospital, Department of Pathology, Paris, France., Baglin AC; Pellegrin Hospital, Centre Michelet, Head and Neck Surgery Department, Bordeaux, France., Janot F; Gustave-Roussy Cancer Campus, Head and Neck Surgery Department, Villejuif, France.
Jazyk:	francouzština
Zdroj:	Bulletin du cancer [Bull Cancer] 2020 May; Vol. 107 (5), pp. 601-611. Date of Electronic Publication: 2020 Apr 15.
DOI:	10.1016/j.bulcan.2020.02.013
Abstrakt:	Sinonasal carcinomas account for 3% of ENT cancers. They are subdivided into squamous cell carcinomas (50%), adenocarcinomas [20%, mostly of intestinal type (ITAC)], and more rarely, adenoid cystic carcinomas, olfactory neuroblastomas (=esthesioneuroblastomas), neuroendocrine carcinomas or undifferentiated sinonasal carcinomas (SNUC). The 5-year survival rates are, in descending order, 72% for neuroblastomas, 63% for adenocarcinomas, 50-60% for large-cell neuroendocrine carcinomas, 53% for squamous cell carcinomas, 25-50% for adenoid cystic, 35% for small-cell neuroendocrine carcinomas and 35% for SNUC and newly discovered histologies. Surgery is the main treatment; endoscopic approaches reduce the morbidity with equivalent tumour control. Intensity-modulated radiation therapy (IMRT) is almost systematic. Nodal involvement is rare in ethmoidal adenocarcinomas and adenoid cystic carcinomas; it is intermediate and may justify prophylactic radiotherapy for N0 necks in SNUC, neuroblastoma, squamous cell carcinomas and sinonasal neuroendocrine carcinomas. IMRT or proton therapy is the mainstay of treatment of unresectable disease. Radiotherapy optimization by carbon ion therapy for adenoid cystic carcinomas, or by chemotherapy for all carcinomas with IMRT or proton therapy, is investigated within clinical trials in France. Neoadjuvant chemotherapy is reserved for rapidly progressive disease or histologies with a high metastatic potential such as neuroendocrine carcinomas or SNUC. Given their histologic and molecular specificities and different relapse patterns, an expertise of the REFCOR network, with REFCORpath review, is likely to correct diagnoses, rectify treatments, with an impact on survival. (Copyright © 2020 Société Française du Cancer. Published by Elsevier Masson SAS. All rights reserved.)
Databáze:	MEDLINE
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