Physical activity reduces anxiety and regulates brain fatty acid synthesis.

Autor: Liśkiewicz A; Laboratory of Molecular Biology, Institute of Physiotherapy and Health Sciences, The Jerzy Kukuczka Academy of Physical Education, Mikołowska 72a, 40-065, Katowice, Poland. adliskiewicz@gmail.com.; Department of Physiology, Faculty of Medical Sciences in Katowice, Medical University of Silesia, Medyków 18, Katowice, 40-752, Poland. adliskiewicz@gmail.com., Przybyła M; Laboratory of Molecular Biology, Institute of Physiotherapy and Health Sciences, The Jerzy Kukuczka Academy of Physical Education, Mikołowska 72a, 40-065, Katowice, Poland.; Department for Experimental Medicine, Faculty of Medical Sciences in Katowice, Medical University of Silesia, Medyków 4, Katowice, 40-752, Poland., Wojakowska A; Institute of Bioorganic Chemistry, Polish Academy of Sciences, 61-704, Poznan, Poland., Marczak Ł; Institute of Bioorganic Chemistry, Polish Academy of Sciences, 61-704, Poznan, Poland., Bogus K; Department of Histology, Faculty of Medical Sciences in Katowice, Medical University of Silesia, Medyków 18, 40-752, Katowice, Poland., Nowacka-Chmielewska M; Laboratory of Molecular Biology, Institute of Physiotherapy and Health Sciences, The Jerzy Kukuczka Academy of Physical Education, Mikołowska 72a, 40-065, Katowice, Poland.; Department for Experimental Medicine, Faculty of Medical Sciences in Katowice, Medical University of Silesia, Medyków 4, Katowice, 40-752, Poland., Liśkiewicz D; Laboratory of Molecular Biology, Institute of Physiotherapy and Health Sciences, The Jerzy Kukuczka Academy of Physical Education, Mikołowska 72a, 40-065, Katowice, Poland.; Department for Experimental Medicine, Faculty of Medical Sciences in Katowice, Medical University of Silesia, Medyków 4, Katowice, 40-752, Poland., Małecki A; Laboratory of Molecular Biology, Institute of Physiotherapy and Health Sciences, The Jerzy Kukuczka Academy of Physical Education, Mikołowska 72a, 40-065, Katowice, Poland., Barski J; Department for Experimental Medicine, Faculty of Medical Sciences in Katowice, Medical University of Silesia, Medyków 4, Katowice, 40-752, Poland., Lewin-Kowalik J; Department of Physiology, Faculty of Medical Sciences in Katowice, Medical University of Silesia, Medyków 18, Katowice, 40-752, Poland., Toborek M; Laboratory of Molecular Biology, Institute of Physiotherapy and Health Sciences, The Jerzy Kukuczka Academy of Physical Education, Mikołowska 72a, 40-065, Katowice, Poland. mtoborek@med.miami.edu.; Department of Biochemistry and Molecular Biology, University of Miami School of Medicine, 1011 NW 15th Street, Miami, FL, 33136, USA. mtoborek@med.miami.edu.
Jazyk: angličtina
Zdroj: Molecular brain [Mol Brain] 2020 Apr 17; Vol. 13 (1), pp. 62. Date of Electronic Publication: 2020 Apr 17.
DOI: 10.1186/s13041-020-00592-7
Abstrakt: Physical activity impacts brain functions, but the direct mechanisms of this effect are not fully recognized or understood. Among multidimensional changes induced by physical activity, brain fatty acids (FA) appear to play an important role; however, the knowledge in this area is particularly scarce. Here we performed global metabolomics profiling of the hippocampus and the frontal cortex (FC) in a model of voluntary running in mice. Examined brain structures responded differentially to physical activity. Specifically, the markers of the tricarboxylic acid (TCA) cycle were downregulated in the FC, whereas glycolysis was enhanced in the hippocampus. Physical activity stimulated production of myristic, palmitic and stearic FA; i.e., the primary end products of de novo lipogenesis in the brain, which was accompanied by increased expression of hippocampal fatty acid synthase (FASN), suggesting stimulation of lipid synthesis. The changes in the brain fatty acid profile were associated with reduced anxiety level in the running mice. Overall, the study examines exercise-related metabolic changes in the brain and links them to behavioral outcomes.
Databáze: MEDLINE
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