The effect of a new oral anticoagulant (Rivaroxaban) on implants pull-out strength. An experimental study in rats.

Autor:	Kapetanou AG; Orthopaedic Department, Aristotle University of Thessaloniki, Thessaloniki, Greece., Savvidis MS; Orthopaedic Department, 424 Military Hospital, Thessaloniki, Greece., Potoupnis ME; Orthopaedic Department, Aristotle University of Thessaloniki, Thessaloniki, Greece., Petsatodis GE; Orthopaedic Department, Aristotle University of Thessaloniki, Thessaloniki, Greece., Kirkos JM; Orthopaedic Department, Aristotle University of Thessaloniki, Thessaloniki, Greece., Kapetanos GA; Orthopaedic Department, Aristotle University of Thessaloniki, Thessaloniki, Greece.
Jazyk:	angličtina
Zdroj:	Journal of frailty, sarcopenia and falls [J Frailty Sarcopenia Falls] 2017 Mar 01; Vol. 2 (1), pp. 1-5. Date of Electronic Publication: 2017 Mar 01 (Print Publication: 2017).
Abstrakt:	Objectives: Thromboprophylaxis reduces the risk of surgery related deep venous thrombosis and pulmonary embolism. The classical anticoagulants (heparin and LWMH) were associated with systemic osteoporosis, poor bone healing and materials' osseointegration. There is a lack of data concerning the effect of the new orally administered anticoagulants on osseointegration. The aim of this study is to investigate the possible effect of rivaroxaban, a direct anti-Xa factor, on osseointegration. Methods: Twenty eight white, male, Wistar rats were divided into two groups: Group A, study group (n=14) and group B, control group (n=14). In all animals under general anesthesia one screw was inserted on the right tibia. For twenty eight days the animals of group A received intraperitoneal rivaroxaban injections 5mgr/kgr every day. The animals of group B received intraperitoneal equal amount of normal saline injections. At the end of the four weeks all animals were sacrificed and their right tibias were excised and underwent the pull-out test. Results: The mean values of pull-out test were 92,10±19,12N for the control group and 95,46±21,02N for the study group. The statistical analysis using t-test showed no significant difference (p=0,665) for the pull-out test. Conclusions: These results indicate that Rivaroxaban hasn't got any deleterious effect on the osseointegration of implants on rats. Competing Interests: The authors have no conflict of interest. (Copyright: © 2017 Hylonome Publications.)
Databáze:	MEDLINE
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