Genome wide association study of 40 clinical measurements in eight dog breeds.

Autor: Momozawa Y; Unit of Animal Genomics, GIGA Institute, University of Liège, Liège, Belgium. momozawa@riken.jp.; Laboratory for Genotyping Development, RIKEN Center for Integrative Medical Sciences, Kanagawa, 230-0045, Japan. momozawa@riken.jp., Merveille AC; Unit of Animal Genomics, GIGA Institute, University of Liège, Liège, Belgium.; Department of Clinical Sciences, Faculty of Veterinary Medicine, University of Liège, Liège, Belgium., Battaille G; Unit of Animal Genomics, GIGA Institute, University of Liège, Liège, Belgium.; Department of Clinical Sciences, Faculty of Veterinary Medicine, University of Liège, Liège, Belgium., Wiberg M; Department of Equine and Small Animal Medicine, Faculty of Veterinary Medicine, University of Helsinki, Helsinki, Finland., Koch J; Faculty of Health and Medical Sciences, University of Copenhagen, 1870, Frederiksberg C, Denmark., Willesen JL; Faculty of Health and Medical Sciences, University of Copenhagen, 1870, Frederiksberg C, Denmark., Proschowsky HF; The Danish Kennel Club, 2680, Solrød Strand, Denmark., Gouni V; U955 - IMRB Inserm and Unité de Cardiologie d'Alfort (UCA), Université Paris-Est, École Nationale Vétérinaire d'Alfort, UPEC, 7 avenue du général de Gaulle, Maisons-Alfort, F-94700, France., Chetboul V; U955 - IMRB Inserm and Unité de Cardiologie d'Alfort (UCA), Université Paris-Est, École Nationale Vétérinaire d'Alfort, UPEC, 7 avenue du général de Gaulle, Maisons-Alfort, F-94700, France., Tiret L; U955 - IMRB, Biology of the neuromuscular system, Inserm, National Veterinary School of Alfort (ENVA), Maisons-Alfort, France., Fredholm M; Faculty of Health and Medical Sciences, University of Copenhagen, 1870, Frederiksberg C, Denmark., Seppälä EH; Department of Veterinary Biosciences, Department of Medical and Clinical Genetics, University of Helsinki, Folkhälsan Research Center, Helsinki, Finland., Lohi H; Department of Veterinary Biosciences, Department of Medical and Clinical Genetics, University of Helsinki, Folkhälsan Research Center, Helsinki, Finland., Georges M; Unit of Animal Genomics, GIGA Institute, University of Liège, Liège, Belgium.; Department of Clinical Sciences, Faculty of Veterinary Medicine, University of Liège, Liège, Belgium., Lequarré AS; Unit of Animal Genomics, GIGA Institute, University of Liège, Liège, Belgium. as.lequarre@uliege.be.; Department of Clinical Sciences, Faculty of Veterinary Medicine, University of Liège, Liège, Belgium. as.lequarre@uliege.be.
Jazyk: angličtina
Zdroj: Scientific reports [Sci Rep] 2020 Apr 16; Vol. 10 (1), pp. 6520. Date of Electronic Publication: 2020 Apr 16.
DOI: 10.1038/s41598-020-63457-y
Abstrakt: The domestic dog represents an ideal model for identifying susceptibility genes, many of which are shared with humans. In this study, we investigated the genetic contribution to individual differences in 40 clinically important measurements by a genome-wide association study (GWAS) in a multinational cohort of 472 healthy dogs from eight breeds. Meta-analysis using the binary effects model after breed-specific GWAS, identified 13 genome-wide significant associations, three of them showed experimental-wide significant associations. We detected a signal at chromosome 13 for the serum concentration of alanine aminotransferase (ALT) in which we detected four breed-specific signals. A large proportion of the variance of ALT (18.1-47.7%) was explained by this locus. Similarly, a single SNP was also responsible for a large proportion of the variance (6.8-78.4%) for other measurements such as fructosamine, stress during physical exam, glucose, and morphometric measurements. The genetic contribution of single variant was much larger than in humans. These findings illustrate the importance of performing meta-analysis after breed-specific GWAS to reveal the genetic contribution to individual differences in clinically important measurements, which would lead to improvement of veterinary medicine.
Databáze: MEDLINE
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