Convergent brain microstructure across multiple genetic models of schizophrenia and autism spectrum disorder: A feasibility study.

Autor: Barnett BR; Neuroscience Training Program, Wisconsin Institutes for Medical Research, University of Wisconsin-Madison, Madison, WI 53705, USA., Casey CP; Neuroscience Training Program, Wisconsin Institutes for Medical Research, University of Wisconsin-Madison, Madison, WI 53705, USA., Torres-Velázquez M; Department of Biomedical Engineering, College of Engineering, University of Wisconsin-Madison, Madison, WI 53706, USA., Rowley PA; Department of Radiology, University of Wisconsin School of Medicine and Public Health, Madison, WI 53705, USA., Yu JJ; Neuroscience Training Program, Wisconsin Institutes for Medical Research, University of Wisconsin-Madison, Madison, WI 53705, USA; Department of Biomedical Engineering, College of Engineering, University of Wisconsin-Madison, Madison, WI 53706, USA; Department of Radiology, University of Wisconsin School of Medicine and Public Health, Madison, WI 53705, USA; Department of Psychiatry, University of Wisconsin School of Medicine and Public Health, Madison, WI 53705, USA. Electronic address: jpyu@uwhealth.org.
Jazyk: angličtina
Zdroj: Magnetic resonance imaging [Magn Reson Imaging] 2020 Jul; Vol. 70, pp. 36-42. Date of Electronic Publication: 2020 Apr 13.
DOI: 10.1016/j.mri.2020.04.002
Abstrakt: Neuroimaging studies of psychiatric illness have revealed a broad spectrum of structural and functional perturbations that have been attributed in part to the complex genetic heterogeneity underpinning these disorders. These perturbations have been identified in both preclinical genetic models and in patients when compared to control populations, but recent work has also demonstrated strong evidence for genetic, molecular, and structural convergence of several psychiatric diseases. We explored potential similarities in neural microstructure in preclinical genetic models of ASD (Fmr1, Nrxn1, Pten) and schizophrenia (Disc1 svΔ2) and in age- and sex-matched control animals with diffusion tensor imaging (DTI) and neurite orientation dispersion and density imaging (NODDI). Our findings demonstrate a convergence in brain microstructure across these four genetic models with both tract-based and region-of-interest based analyses, which continues to buttress an emerging understanding of converging neural microstructure in psychiatric disease.
(Copyright © 2020 Elsevier Inc. All rights reserved.)
Databáze: MEDLINE
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