| Autor: |
Yang S; Department of Imaging, Second Affiliated Hospital of Soochow University, Suzhou 215004, China., Zhang YY; Department of Imaging, Second Affiliated Hospital of Soochow University, Suzhou 215004, China., Zhao WL; Department of Imaging, Second Affiliated Hospital of Soochow University, Suzhou 215004, China., Wei CG; Department of Imaging, Second Affiliated Hospital of Soochow University, Suzhou 215004, China., Chen T; Department of Imaging, Second Affiliated Hospital of Soochow University, Suzhou 215004, China., Li MJ; Department of Imaging, Second Affiliated Hospital of Soochow University, Suzhou 215004, China., Tan SX; Department of Imaging, Second Affiliated Hospital of Soochow University, Suzhou 215004, China., Shen JK; Department of Imaging, Second Affiliated Hospital of Soochow University, Suzhou 215004, China. |
| Jazyk: |
čínština |
| Zdroj: |
Zhonghua yi xue za zhi [Zhonghua Yi Xue Za Zhi] 2020 Apr 07; Vol. 100 (13), pp. 997-1001. |
| DOI: |
10.3760/cma.j.cn112137-20190815-01814 |
| Abstrakt: |
Objective: To explore the decision-making value of clinical data in prostate imaging reporting and data system version 2 (PI-RADS V2) 3 lesions, and to compare the diagnostic value of related data for prostate cancer (PCa) and clinically PCa(csPCa). Methods: From March 2016 to October 2018,a subset of 121 men with 121 PI-RADS 3 index lesions were retrospectively analyzed. There were 31 PCa lesions and 14 csPCa lesions, aged from 46 to 91 years with a mean age of (71±9) years. The clinical data of the age, prostate specific antigen (PSA), free PSA (fPSA), f/tPSA, PSA density (PSAD) and prostate volume (PV) were compared between PCa group and non-PCa group, csPCa group and non-csPCa group using univariate analysis, respectively.The receiver operating characteristic (ROC) curve was used to evaluate the efficiency of statistically data in detecting PCa and csPCa in men with PI-RADS 3 index lesions. Results: The differences of PSA, f/tPSA and PSAD were all statistically significant ( Z= -2.004, -2.527, -2.623, all P< 0.05) between PCa group and non-PCa group, and they were all also statistically significant( Z= -2.415, -2.158, -2.870, all P< 0.05) between csPCa group and non-csPCa group. Both PSAD had the best diagnostic efficiency, the ROC curve of detecting PCa and csPCa was 0.658 and 0.736, respectively. If used PSAD>0.20 μg·L(-1)·ml(-1) as the biopsy threshold, the sensitivity, specificity, positive predictive value and negative predictive value of csPCa were 78.6%, 58.9%, 20.0%, 95.4%, and 54.5% (66/121) of the enrolled men can avoid biopsy, resulting only 3 cases of csPCa missed. Conclusion: PSA, f/tPSA, PSAD, especially PSAD can improve the detection efficiency of PCa,especially csPCa in PI-RADS 3 lesions, assisting clinical decision-making. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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