Fibrinogen concentrations in ischaemic stroke patients with metabolic disorders.
| Autor: | Pawelczyk M; Department of Neurology and Stroke, Medical University of Lodz, Poland. malgorzata.pawelczyk@umed.lodz.pl., Kaczorowska B; Department of Neurology and Stroke, Medical University of Lodz, Poland., Baj Z; Department of Pathophysiology and Clinical Immunology, Medical University of Lodz, Poland. |
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| Jazyk: | angličtina |
| Zdroj: | Neurologia i neurochirurgia polska [Neurol Neurochir Pol] 2020; Vol. 54 (3), pp. 259-264. Date of Electronic Publication: 2020 Apr 15. |
| DOI: | 10.5603/PJNNS.a2020.0035 |
| Abstrakt: | Background: Hyperfibrinogenemia plays a crucial role in the coagulation cascade leading to the formation of clots. It is involved in the process of platelet aggregation, primary haemostasis, and leukocyte-endothelial cell interactions. The aim of our study was to assess the correlations between fibrinogen concentration and particular risk factors for vascular diseases and atherosclerotic changes in stroke patients. Methods: The study group consisted with 94 patients with acute ischaemic stroke with normo- or hyperglycaemia and normoor hyperlipidemia. 21 healthy subjects served as a control group. Fibrinogen level, HbA1c, and lipid profile were measured in all patients. Using a flow cytometer, we assessed CD61 positive microparticles which were defined as platelet-derived microparticles (PDMPs). The level of sP-selectin in serum was measured using the ELISA method. Results: A significant positive correlation was observed between fibrinogen concentration and sP-selectin (p = 0.001), HbA1c (p < 0.05) level, and percentage of PDMPs (p < 0.05) in the study patients. Furthermore, we noticed a significant negative correlation between fibrinogen concentration and the level of HDL (p < 0.05). No correlation was observed between fibrinogen and TC, LDL and TG levels. Conclusions and Clinical Implications: Our findings suggest that an elevated fibrinogen level may represent a marker of prothrombotic condition exacerbated in the state of hyperglycaemia and activation of platelets and endothelial cells. This suggests an important role played by fibrinogen in the process of thrombogenesis. |
| Databáze: | MEDLINE |
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