Similarities in clinical course and outcome between juvenile idiopathic arthritis (JIA)-associated and ANA-positive idiopathic anterior uveitis: data from a population-based nationwide study in Germany.

Autor: Heiligenhaus A; Department of Ophthalmology at St. Franziskus Hospital, Muenster, Hohenzollernring 74, 48145, Muenster, Germany. arnd.heiligenhaus@uveitis-zentrum.de.; University of Duisburg-Essen, Duisburg, Germany. arnd.heiligenhaus@uveitis-zentrum.de., Klotsche J; German Rheumatism Research Center, a Leibniz Institute, Berlin, Germany.; Charité - University Medicine Berlin, Institute for Social Medicine, Epidemiology and Health Economics, Berlin, Germany., Niewerth M; German Rheumatism Research Center, a Leibniz Institute, Berlin, Germany., Horneff G; Asklepios Clinic Sankt Augustin GmbH, Sankt Augustin, Germany.; Department of Pediatric and Adolescent Medicine, Medical Faculty, University Hospital of Cologne, Cologne, Germany., Ganser G; Sankt Josef-Stift Sendenhorst, Sendenhorst, Germany., Haas JP; German Centre for Pediatric and Adolescent Rheumatology, Garmisch-Partenkirchen, Germany., Minden K; German Rheumatism Research Center, a Leibniz Institute, Berlin, Germany.; Department of Rheumatology and Clinical Immunology, Charité - University Medicine Berlin, Berlin, Germany.
Jazyk: angličtina
Zdroj: Arthritis research & therapy [Arthritis Res Ther] 2020 Apr 15; Vol. 22 (1), pp. 81. Date of Electronic Publication: 2020 Apr 15.
DOI: 10.1186/s13075-020-02166-3
Abstrakt: Background: To analyze whether ANA-positive idiopathic anterior uveitis differs from JIA-associated uveitis concerning clinical course, response to treatment, and disease outcome.
Methods: Prospective study of the National Paediatric Rheumatological Database (NPRD) including its uveitis add-on module from the years 2002 to 2016. Cross-sectional data from the years 2002 to 2016 were analyzed. Patients with JIA-associated uveitis and with ANA-positive idiopathic anterior uveitis were included and the disease manifestation investigated in terms of uveitis characteristics and disease course.
Results: Of the total cohort of 34,458 patients enrolled in the NPRD, including 3551 patients with uveitis, those with detailed uveitis documentation were taken into account: 62 ANA-positive patients with idiopathic anterior uveitis (group 1), 688 patients with initial uveitis diagnosis after JIA onset (group 2), and 61 JIA patients with initial uveitis diagnosis before arthritis onset (group 3). Anterior uveitis was documented in 100%, 94%, and 80% of patients and with insidious onset of uveitis flare in 50%, 70.9%, and 56.1% each in groups 1, 2, and 3, respectively. Use of topical or systemic corticosteroids and conventional synthetic or biological DMARDs did not significantly differ between the patient groups, either at the initial or the 2-year follow-up (2-FU) visits (mean 2 years, each p > 0.05). At 2-FU, uveitis inactivity was achieved in 64.7%, 55.8%, and 61.5% of patients in groups 1, 2, and 3 (p > 0.05). Uveitis-related complications were more frequent at the initial visit and at 2-FU in groups 1 and 3, as compared to group 2.
Conclusions: ANA-positive idiopathic uveitis and JIA-associated uveitis do not significantly differ concerning clinical course of uveitis, treatment, and response to corticosteroids and DMARDs.
Databáze: MEDLINE
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