Prognostic markers in Chronic Lymphocytic Leukaemia - A flow cytometric analysis.

Autor: Haq H; Dr. Hala Haq, MBBS, M.Phil (Hematology). Demonstrator Pathology, Fazaia Medical College, Islamabad, Pakistan., Uddin N; Col. Nasir Uddin, MBBS, FCPS. Assistant Professor Pathology, Army Medical College, Rawalpindi, Pakistan., Khan SA; Maj. Gen. Saleem Ahmed Khan, HI (M), MBBS, MCPS, FCPS, FRCP, PhD. Professor Pathology and Principal, Army Medical College, Rawalpindi, Pakistan., Ghaffar S; Dr. Sunia Ghaffar, MBBS, M. Phil. Army Medical College, Rawalpindi, Pakistan.
Jazyk: angličtina
Zdroj: Pakistan journal of medical sciences [Pak J Med Sci] 2020 Mar-Apr; Vol. 36 (3), pp. 338-343.
DOI: 10.12669/pjms.36.3.541
Abstrakt: Objective: To find out the frequency of ZAP-70, CD38 and CD49d in patients diagnosed with CLL in our population.
Methods: This is a cross sectional study conducted in Army Medical College in collaboration with Armed Forces Institute of Pathology and Military Hospital Rawalpindi from 1 st January 2018 to 30 th November 2018. Permission from Institutional Ethical Committee was obtained. Blood samples were collected by non-probability consecutive sampling technique and analyzed for blood counts and flow cytometry was done for ZAP-70, CD38 and CD49d. Manufacturer's instructions for the kits were strictly followed.
Results: Fifty-one newly diagnosed patients with CLL were studied for the prognostic markers in CLL. CD 38 was expressed in 25(49%) and CD49d in 21(41.2%). ZAP-70 expression was not detected in our series of patients.
Conclusion: We conclude that CD38 and CD49d expression was detected in almost half of the patients of CLL in our series. CD49d showed statistically positive correlation with CD38, showing that it is a more pragmatic choice for reliable prognostication of CLL along with CD38.
Competing Interests: Conflict of interest: There is no conflict of interest among the authors.
(Copyright: © Pakistan Journal of Medical Sciences.)
Databáze: MEDLINE
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