Acute exacerbated severe form of nonalcoholic steatohepatitis leading to acute-on-chronic liver failure: A case series.

Autor: Philips CA; The Liver Unit, Monarch Liver Lab and Division of Gastroenterology, Cochin Gastroenterology Group, Ernakulam Medical Centre, National Highway Bypass, Palarivattom, Kochi, 682 028, India. abbyphilips@gmail.com.; Philip Augustine Associates, 35/194 B, Symphony, Automobile Road, Palarivattom, Kochi, 682 025, India. abbyphilips@gmail.com., Augustine P; The Liver Unit, Monarch Liver Lab and Division of Gastroenterology, Cochin Gastroenterology Group, Ernakulam Medical Centre, National Highway Bypass, Palarivattom, Kochi, 682 028, India.; Philip Augustine Associates, 35/194 B, Symphony, Automobile Road, Palarivattom, Kochi, 682 025, India., Ahamed R; The Liver Unit, Monarch Liver Lab and Division of Gastroenterology, Cochin Gastroenterology Group, Ernakulam Medical Centre, National Highway Bypass, Palarivattom, Kochi, 682 028, India., Rajesh S; The Liver Unit, Monarch Liver Lab and Division of Gastroenterology, Cochin Gastroenterology Group, Ernakulam Medical Centre, National Highway Bypass, Palarivattom, Kochi, 682 028, India., George T; The Liver Unit, Monarch Liver Lab and Division of Gastroenterology, Cochin Gastroenterology Group, Ernakulam Medical Centre, National Highway Bypass, Palarivattom, Kochi, 682 028, India., Kumbar S; The Liver Unit, Monarch Liver Lab and Division of Gastroenterology, Cochin Gastroenterology Group, Ernakulam Medical Centre, National Highway Bypass, Palarivattom, Kochi, 682 028, India., Padsalgi G; The Liver Unit, Monarch Liver Lab and Division of Gastroenterology, Cochin Gastroenterology Group, Ernakulam Medical Centre, National Highway Bypass, Palarivattom, Kochi, 682 028, India., Mahadevan P; Pathology, VPS Lakeshore Hospital, Maradu, Nettoor, Kochi, 682 018, India.
Jazyk: angličtina
Zdroj: Indian journal of gastroenterology : official journal of the Indian Society of Gastroenterology [Indian J Gastroenterol] 2020 Feb; Vol. 39 (1), pp. 97-101. Date of Electronic Publication: 2020 Apr 14.
DOI: 10.1007/s12664-020-01028-9
Abstrakt: We present three patients with uncontrolled metabolic syndrome and acute-on-chronic liver failure in whom, after meticulous evaluation, the acute event was found to be a severe and exacerbated form of nonalcoholic steatohepatitis (NASH), a novel entry in the natural history of non-alcoholic fatty liver disease. This novel disease entity was described partially, 17 years before by Caldwell et al. We discuss current literature, pertinent features, and outcomes associated with a severe form of NASH, which is associated with high mortality.
Databáze: MEDLINE
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