Rotational field TMS: Comparison with conventional TMS based on motor evoked potentials and thresholds in the hand and leg motor cortices.

Autor: Roth Y; Brainsway Ltd, Israel; Department of Life Sciences, Ben-Gurion University, Beer Sheva, Israel., Pell GS; Brainsway Ltd, Israel; Department of Life Sciences, Ben-Gurion University, Beer Sheva, Israel., Barnea-Ygael N; Department of Life Sciences, Ben-Gurion University, Beer Sheva, Israel., Ankry M; Brainsway Ltd, Israel., Hadad Y; Brainsway Ltd, Israel., Eisen A; The Department of Physics of Complex Systems, The Weizmann Institute of Science, Rehovot, Israel., Burnishev Y; The Department of Physics of Complex Systems, The Weizmann Institute of Science, Rehovot, Israel., Tendler A; Brainsway Ltd, Israel; Department of Life Sciences, Ben-Gurion University, Beer Sheva, Israel; Advanced Mental Health Care Inc., Israel., Moses E; The Department of Physics of Complex Systems, The Weizmann Institute of Science, Rehovot, Israel., Zangen A; Department of Life Sciences, Ben-Gurion University, Beer Sheva, Israel. Electronic address: azangen@bgu.ac.il.
Jazyk: angličtina
Zdroj: Brain stimulation [Brain Stimul] 2020 May - Jun; Vol. 13 (3), pp. 900-907. Date of Electronic Publication: 2020 Mar 23.
DOI: 10.1016/j.brs.2020.03.010
Abstrakt: Background: Transcranial magnetic stimulation (TMS) is a rapidly expanding technology utilized in research and neuropsychiatric treatments. Yet, conventional TMS configurations affect primarily neurons that are aligned parallel to the induced electric field by a fixed coil, making the activation orientation-specific. A novel method termed rotational field TMS (rfTMS), where two orthogonal coils are operated with a 90° phase shift, produces rotation of the electric field vector over almost a complete cycle, and may stimulate larger portion of the neuronal population within a given brain area.
Objective: To compare the physiological effects of rfTMS and conventional unidirectional TMS (udTMS) in the motor cortex.
Methods: Hand and leg resting motor thresholds (rMT), and motor evoked potential (MEP) amplitudes and latencies (at 120% of rMT), were measured using a dual-coil array based on the H7-coil, in 8 healthy volunteers following stimulation at different orientations of either udTMS or rfTMS.
Results: For both target areas rfTMS produced significantly lower rMTs and much higher MEPs than those induced by udTMS, for comparable induced electric field amplitude. Both hand and leg rMTs were orientation-dependent.
Conclusions: rfTMS induces stronger physiologic effects in targeted brain regions at significantly lower intensities. Importantly, given the activation of a much larger population of neurons within a certain brain area, repeated application of rfTMS may induce different neuroplastic effects in neural networks, opening novel research and clinical opportunities.
Competing Interests: Declaration of competing interest AZ and YR are inventors of deep TMS technology and have financial interest in Brainsway Ltd., a company that develops and commercialize deep TMS devices. GSP, MA, YH and AT are Brainsway employees. All other authors declare no competing interest.
(Copyright © 2020 The Author(s). Published by Elsevier Inc. All rights reserved.)
Databáze: MEDLINE
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