Characterizing Emerging Canine H3 Influenza Viruses.

Autor: Martinez-Sobrido L; Department of Microbiology and Immunology, University of Rochester, Rochester, New York, United States of America., Blanco-Lobo P; Department of Microbiology and Immunology, University of Rochester, Rochester, New York, United States of America., Rodriguez L; Department of Microbiology and Immunology, University of Rochester, Rochester, New York, United States of America., Fitzgerald T; David H. Smith Center for Vaccine Biology and Immunology, University of Rochester, Rochester, New York, United States of America., Zhang H; Department of Dermatology, University of Rochester, Rochester, New York, United States of America.; Materials Science Program, University of Rochester, Rochester, New York, United States of America., Nguyen P; David H. Smith Center for Vaccine Biology and Immunology, University of Rochester, Rochester, New York, United States of America., Anderson CS; David H. Smith Center for Vaccine Biology and Immunology, University of Rochester, Rochester, New York, United States of America., Holden-Wiltse J; Department of Biostatistics and Computational Biology and Clinical and Translational Science Institute, University of Rochester, Rochester, New York, United States of America., Bandyopadhyay S; Department of Biostatistics and Computational Biology and Clinical and Translational Science Institute, University of Rochester, Rochester, New York, United States of America., Nogales A; Department of Microbiology and Immunology, University of Rochester, Rochester, New York, United States of America., DeDiego ML; David H. Smith Center for Vaccine Biology and Immunology, University of Rochester, Rochester, New York, United States of America., Wasik BR; Baker Institute for Animal Health, Department of Microbiology and Immunology, College of Veterinary Medicine, Cornell University, Ithaca, New York, United States of America., Miller BL; Department of Dermatology, University of Rochester, Rochester, New York, United States of America.; Materials Science Program, University of Rochester, Rochester, New York, United States of America., Henry C; The Department of Medicine, Section of Rheumatology, The Knapp Center for Lupus and Immunology Research, The University of Chicago, Chicago, Illinois, United States of America., Wilson PC; The Department of Medicine, Section of Rheumatology, The Knapp Center for Lupus and Immunology Research, The University of Chicago, Chicago, Illinois, United States of America., Sangster MY; David H. Smith Center for Vaccine Biology and Immunology, University of Rochester, Rochester, New York, United States of America., Treanor JJ; David H. Smith Center for Vaccine Biology and Immunology, University of Rochester, Rochester, New York, United States of America., Topham DJ; David H. Smith Center for Vaccine Biology and Immunology, University of Rochester, Rochester, New York, United States of America., Byrd-Leotis L; Department of Microbiology and Immunology, Emory University School of Medicine, Atlanta, Georgia, United States of America.; Beth Israel Deaconess Medical Center, Department of Surgery and Harvard Medical School Center for Glycoscience, Harvard Medical School, Boston, Massachusetts, United States of America., Steinhauer DA; Department of Microbiology and Immunology, Emory University School of Medicine, Atlanta, Georgia, United States of America., Cummings RD; Department of Microbiology and Immunology, Emory University School of Medicine, Atlanta, Georgia, United States of America.; Beth Israel Deaconess Medical Center, Department of Surgery and Harvard Medical School Center for Glycoscience, Harvard Medical School, Boston, Massachusetts, United States of America., Luczo JM; Center for Vaccines and Immunology, University of Georgia, Athens, Georgia, United States of America., Tompkins SM; Center for Vaccines and Immunology, University of Georgia, Athens, Georgia, United States of America., Sakamoto K; Department of Pathology, University of Georgia, Athens, Georgia, United States of America., Jones CA; Center for Vaccines and Immunology, University of Georgia, Athens, Georgia, United States of America., Steel J; Department of Microbiology and Immunology, Emory University School of Medicine, Atlanta, Georgia, United States of America., Lowen AC; Department of Microbiology and Immunology, Emory University School of Medicine, Atlanta, Georgia, United States of America., Danzy S; Department of Microbiology and Immunology, Emory University School of Medicine, Atlanta, Georgia, United States of America., Tao H; Department of Microbiology and Immunology, Emory University School of Medicine, Atlanta, Georgia, United States of America., Fink AL; W. Harry Feinstone Department of Molecular Microbiology and Immunology, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland, United States of America., Klein SL; W. Harry Feinstone Department of Molecular Microbiology and Immunology, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland, United States of America., Wohlgemuth N; W. Harry Feinstone Department of Molecular Microbiology and Immunology, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland, United States of America., Fenstermacher KJ; W. Harry Feinstone Department of Molecular Microbiology and Immunology, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland, United States of America., El Najjar F; W. Harry Feinstone Department of Molecular Microbiology and Immunology, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland, United States of America., Pekosz A; W. Harry Feinstone Department of Molecular Microbiology and Immunology, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland, United States of America., Sauer L; Department of Emergency Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland, United States of America., Lewis MK; Department of Emergency Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland, United States of America., Shaw-Saliba K; Department of Emergency Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland, United States of America., Rothman RE; Department of Emergency Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland, United States of America., Liu ZY; Department of Emergency Medicine, Chang Gung Memorial Hospital, Taiwan., Chen KF; Department of Emergency Medicine, Chang Gung Memorial Hospital, Taiwan., Parrish CR; Baker Institute for Animal Health, Department of Microbiology and Immunology, College of Veterinary Medicine, Cornell University, Ithaca, New York, United States of America., Voorhees IEH; Baker Institute for Animal Health, Department of Microbiology and Immunology, College of Veterinary Medicine, Cornell University, Ithaca, New York, United States of America., Kawaoka Y; Influenza Research Institute, Department of Pathobiological Sciences, School of Veterinary Medicine, University of Wisconsin-Madison. Madison, Wisconsin, United States of America., Neumann G; Influenza Research Institute, Department of Pathobiological Sciences, School of Veterinary Medicine, University of Wisconsin-Madison. Madison, Wisconsin, United States of America., Chiba S; Influenza Research Institute, Department of Pathobiological Sciences, School of Veterinary Medicine, University of Wisconsin-Madison. Madison, Wisconsin, United States of America., Fan S; Influenza Research Institute, Department of Pathobiological Sciences, School of Veterinary Medicine, University of Wisconsin-Madison. Madison, Wisconsin, United States of America., Hatta M; Influenza Research Institute, Department of Pathobiological Sciences, School of Veterinary Medicine, University of Wisconsin-Madison. Madison, Wisconsin, United States of America., Kong H; Influenza Research Institute, Department of Pathobiological Sciences, School of Veterinary Medicine, University of Wisconsin-Madison. Madison, Wisconsin, United States of America., Zhong G; Influenza Research Institute, Department of Pathobiological Sciences, School of Veterinary Medicine, University of Wisconsin-Madison. Madison, Wisconsin, United States of America., Wang G; Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, New York, United States of America.; Global Health and Emerging Pathogens Institute, Icahn School of Medicine at Mount Sinai, New York, New York, United States of America., Uccellini MB; Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, New York, United States of America.; Global Health and Emerging Pathogens Institute, Icahn School of Medicine at Mount Sinai, New York, New York, United States of America., García-Sastre A; Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, New York, United States of America.; Global Health and Emerging Pathogens Institute, Icahn School of Medicine at Mount Sinai, New York, New York, United States of America.; Department of Medicine, Division of Infectious Diseases, Icahn School of Medicine at Mount Sinai, New York, New York, United States of America.; The Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, New York, United States of America., Perez DR; Department of Population Health, University of Georgia, Athens, Georgia, United States of America., Ferreri LM; Department of Population Health, University of Georgia, Athens, Georgia, United States of America., Herfst S; Department of Viroscience, Erasmus MC, Rotterdam, The Netherlands., Richard M; Department of Viroscience, Erasmus MC, Rotterdam, The Netherlands., Fouchier R; Department of Viroscience, Erasmus MC, Rotterdam, The Netherlands., Burke D; Center for Pathogen Evolution, Department of Zoology, University of Cambridge, Cambridge, United Kingdom., Pattinson D; Center for Pathogen Evolution, Department of Zoology, University of Cambridge, Cambridge, United Kingdom., Smith DJ; Center for Pathogen Evolution, Department of Zoology, University of Cambridge, Cambridge, United Kingdom., Meliopoulos V; Department of Infectious Diseases, St. Jude Children's Research Hospital, Memphis, Tennessee, United States of America., Freiden P; Department of Infectious Diseases, St. Jude Children's Research Hospital, Memphis, Tennessee, United States of America., Livingston B; Department of Infectious Diseases, St. Jude Children's Research Hospital, Memphis, Tennessee, United States of America., Sharp B; Department of Infectious Diseases, St. Jude Children's Research Hospital, Memphis, Tennessee, United States of America., Cherry S; Department of Infectious Diseases, St. Jude Children's Research Hospital, Memphis, Tennessee, United States of America., Dib JC; Tropical Health Foundation, Santa Marta, Magdalena, Colombia., Yang G; Department of Infectious Diseases, St. Jude Children's Research Hospital, Memphis, Tennessee, United States of America., Russell CJ; Department of Infectious Diseases, St. Jude Children's Research Hospital, Memphis, Tennessee, United States of America., Barman S; Department of Infectious Diseases, St. Jude Children's Research Hospital, Memphis, Tennessee, United States of America., Webby RJ; Department of Infectious Diseases, St. Jude Children's Research Hospital, Memphis, Tennessee, United States of America., Krauss S; Department of Infectious Diseases, St. Jude Children's Research Hospital, Memphis, Tennessee, United States of America., Danner A; Department of Infectious Diseases, St. Jude Children's Research Hospital, Memphis, Tennessee, United States of America., Woodard K; Department of Infectious Diseases, St. Jude Children's Research Hospital, Memphis, Tennessee, United States of America., Peiris M; School of Public Health, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong Special Administrative Region, Republic of China., Perera RAPM; School of Public Health, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong Special Administrative Region, Republic of China., Chan MCW; School of Public Health, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong Special Administrative Region, Republic of China., Govorkova EA; Department of Infectious Diseases, St. Jude Children's Research Hospital, Memphis, Tennessee, United States of America., Marathe BM; Department of Infectious Diseases, St. Jude Children's Research Hospital, Memphis, Tennessee, United States of America., Pascua PNQ; Department of Infectious Diseases, St. Jude Children's Research Hospital, Memphis, Tennessee, United States of America., Smith G; Programme in Emerging Infectious Diseases, Duke-NUS Medical School, Singapore., Li YT; Programme in Emerging Infectious Diseases, Duke-NUS Medical School, Singapore., Thomas PG; Department of Immunology, St. Jude Children's Research Hospital, Memphis, Tennessee, United States of America., Schultz-Cherry S; Department of Infectious Diseases, St. Jude Children's Research Hospital, Memphis, Tennessee, United States of America.
Jazyk: angličtina
Zdroj: PLoS pathogens [PLoS Pathog] 2020 Apr 14; Vol. 16 (4), pp. e1008409. Date of Electronic Publication: 2020 Apr 14 (Print Publication: 2020).
DOI: 10.1371/journal.ppat.1008409
Abstrakt: The continual emergence of novel influenza A strains from non-human hosts requires constant vigilance and the need for ongoing research to identify strains that may pose a human public health risk. Since 1999, canine H3 influenza A viruses (CIVs) have caused many thousands or millions of respiratory infections in dogs in the United States. While no human infections with CIVs have been reported to date, these viruses could pose a zoonotic risk. In these studies, the National Institutes of Allergy and Infectious Diseases (NIAID) Centers of Excellence for Influenza Research and Surveillance (CEIRS) network collaboratively demonstrated that CIVs replicated in some primary human cells and transmitted effectively in mammalian models. While people born after 1970 had little or no pre-existing humoral immunity against CIVs, the viruses were sensitive to existing antivirals and we identified a panel of H3 cross-reactive human monoclonal antibodies (hmAbs) that could have prophylactic and/or therapeutic value. Our data predict these CIVs posed a low risk to humans. Importantly, we showed that the CEIRS network could work together to provide basic research information important for characterizing emerging influenza viruses, although there were valuable lessons learned.
Competing Interests: AG-S. is inventor of patents on influenza virus vaccines owned by the Icahn School for Medicine at Mount Sinai and licensed to Medimmune, BI Vetmedica, Vivaldi Biosciences, Zoetis and Avimex.
Databáze: MEDLINE
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