A randomized clinical trial of sildenafil plus clomiphene citrate to improve the success rate of ovulation induction in patients with unexplained infertility.

Autor: Aboelroose AA; Department of Obstetrics and Gynecology, Faculty of Medicine, Suez Canal University, Ismailia, Egypt., Ibrahim ZM; Department of Obstetrics and Gynecology, Faculty of Medicine, Suez Canal University, Ismailia, Egypt., Madny EH; Department of Obstetrics and Gynecology, Faculty of Medicine, Suez Canal University, Ismailia, Egypt., Elmazzahy AM; Department of Obstetrics and Gynecology, Faculty of Medicine, Suez Canal University, Ismailia, Egypt., Taha OT; Department of Obstetrics and Gynecology, Faculty of Medicine, Suez Canal University, Ismailia, Egypt.
Jazyk: angličtina
Zdroj: International journal of gynaecology and obstetrics: the official organ of the International Federation of Gynaecology and Obstetrics [Int J Gynaecol Obstet] 2020 Jul; Vol. 150 (1), pp. 72-76. Date of Electronic Publication: 2020 May 07.
DOI: 10.1002/ijgo.13159
Abstrakt: Objectives: To investigate the role of sildenafil citrate in improving ovulation induction success rate in women with unexplained infertility.
Methods: A randomized clinical trial from January to December 2018 of 80 women with unexplained infertility randomized into two groups. Both groups received 100 mg clomiphene citrate once daily from days 3-7 of the menstrual cycle. The study group also received 25 mg oral sildenafil citrate twice daily from days 8-12 of the same cycle. Transvaginal ultrasound assessed ovulation, endometrial thickness, and number of follicles. Pregnancy was assessed 2 weeks after ovulation. Primary outcome measures were endometrial thickness, number of mature follicles, and pregnancy rates.
Results: Pregnancy rates (26 (65%) and 16 (40%), P=0.043) and endometrial thickness (10.4 ± 1.4 and 9.2 ± 1.9, P=0.007) were significantly higher in the study group. More women in the study group reported adverse effects compared with the control group (17 [42.5%] vs 9 [22.5%]; P=0.034), with headache the most common adverse effect in the study group, reported by 8 (20.0%) patients.
Conclusion: Adding sildenafil citrate improved ovulation success rate and increased pregnancy rate.
Pan African Clinical Trial Registry: PACTR201907658492123.
(© 2020 International Federation of Gynecology and Obstetrics.)
Databáze: MEDLINE
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