| Autor: |
Chebabo SR; Departamento de Neurobiologia, Universidade Federal do Rio de Janeiro, Brasil., Do-Carmo RJ, Martins-Ferreira H |
| Jazyk: |
angličtina |
| Zdroj: |
Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas [Braz J Med Biol Res] 1988; Vol. 21 (3), pp. 603-5. |
| Abstrakt: |
The present study examines the effect of diphenylhydantoin on the elicitation by K+ and propagation of spreading depression in chick retina preparations in vitro. A dose-related decrease in the velocity of propagation was observed, this effect being lessened by increasing the pH of the Ringer bathing the preparation. Changes in Ringer Cl- concentration also altered the efficacy of the drug, higher concentrations enhancing and lower concentrations reducing efficacy. The threshold concentration of K+ necessary to elicit the reaction was elevated by diphenylhydantoin. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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