| Autor: |
Mervin LH; Centre for Molecular Informatics, Department of Chemistry, University of Cambridge, Cambridge, UK., Mitricheva E; Department of Physiology of Cognitive Processes, Max Planck Institute for Biological Cybernetics, Tübingen, Germany., Logothetis NK; Department of Physiology of Cognitive Processes, Max Planck Institute for Biological Cybernetics, Tübingen, Germany.; Imaging Science and Biomedical Engineering, University of Manchester, Manchester, UK., Bifone A; Department of Molecular Biotechnology and Health Sciences, University of Torino, Torino, Italy.; Center for Neuroscience and Cognitive Systems, Istituto Italiano di Tecnologia, Rovereto, Italy., Bender A; Centre for Molecular Informatics, Department of Chemistry, University of Cambridge, Cambridge, UK., Noori HR; Department of Physiology of Cognitive Processes, Max Planck Institute for Biological Cybernetics, Tübingen, Germany.; McGovern Institute for Brain Research, Massachusetts Institute of Technology, Cambridge, MA, USA. |
| Abstrakt: |
Functional magnetic resonance imaging (fMRI) is an extensively used method for the investigation of normal and pathological brain function. In particular, fMRI has been used to characterize spatiotemporal hemodynamic response to pharmacological challenges as a non-invasive readout of neuronal activity. However, the mechanisms underlying regional signal changes are yet unclear. In this study, we use a meta-analytic approach to converge data from microdialysis experiments with relative cerebral blood volume (rCBV) changes following acute administration of neuropsychiatric drugs in adult male rats. At whole-brain level, the functional response patterns show very weak correlation with neurochemical alterations, while for numerous brain areas a strong positive correlation with noradrenaline release exists. At a local scale of individual brain regions, the rCBV response to neurotransmitters is anatomically heterogeneous and, importantly, based on a complex interplay of different neurotransmitters that often exert opposing effects, thus providing a mechanism for regulating and fine tuning hemodynamic responses in specific regions. |
