Ageing and cognition in men with fragile X syndrome.
| Autor: | Sauna-Aho O; KTO-Special Welfare District of Varsinais-Suomi, Paimio, Finland.; Public Health, Turku University Hospital, Turku University, Turku, Finland., Bjelogrlic-Laakso N; Tampere University Hospital, Special Welfare District of Pirkanmaa, Tampere, Finland., Rautava P; Public Health, Turku University Hospital, Turku University, Turku, Finland., Arvio M; Clinical Genetics, Turku University Hospital, Turku, Finland.; Neurology, Päijät-Häme Joint Municipal Authority, Lahti, Finland.; PEDEGO, University of Oulu, Oulu, Finland. |
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| Jazyk: | angličtina |
| Zdroj: | Journal of applied research in intellectual disabilities : JARID [J Appl Res Intellect Disabil] 2020 Sep; Vol. 33 (5), pp. 1113-1118. Date of Electronic Publication: 2020 Apr 12. |
| DOI: | 10.1111/jar.12733 |
| Abstrakt: | Background: Fragile X syndrome (FXS) is the most common inherited cause of intellectual disability. The aim of our longitudinal study was to describe ageing-related cognitive changes in men with FXS. Method: A neuropsychologist determined the raw scores (RSs) of 19 men with FXS twice with the Leiter International Performance Scale at an average interval of 22 years. The ages of the participants at baseline ranged from 16 to 50 (mean 27) years. Results: At follow-up, the RSs improved in two men, remained the same in two men and declined in 15 men. Overall, the RS of the study group deteriorated by an average 4 points in RSs (p < .001). Conclusion: Cognitive ageing in men with FXS started earlier than that in men in the general population; in many cases, cognitive ageing in men with FXS began before middle age, usually without any medical or other underlying cause. (© 2020 The Authors. Journal of Applied Research in Intellectual Disabilities published by John Wiley & Sons Ltd.) |
| Databáze: | MEDLINE |
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