Neuroinflammatory Markers in the Serum of Prepubertal Children with Down Syndrome.

Autor: Tarani L; Department of Pediatrics, Sapienza University Hospital of Rome, Italy., Carito V; Institute of Biochemistry and Cell Biology, Section of Neurobiology, National Research Council (IBBC-CNR), Rome, Italy., Ferraguti G; Department of Cellular Biotechnologies and Hematology, Sapienza University Hospital of Rome, Italy., Petrella C; Institute of Biochemistry and Cell Biology, Section of Neurobiology, National Research Council (IBBC-CNR), Rome, Italy., Greco A; Department of Sense Organs, Sapienza University Hospital of Rome, Italy., Ralli M; Department of Sense Organs, Sapienza University Hospital of Rome, Italy., Messina MP; Department of Obstetrics and Gynecology, Sapienza University Hospital of Rome, Italy., Rasio D; San Raffaele Roma Open University, Rome, Italy., De Luca E; Department of Pediatrics, Sapienza University Hospital of Rome, Italy., Putotto C; Department of Pediatrics, Sapienza University Hospital of Rome, Italy., Versacci P; Department of Pediatrics, Sapienza University Hospital of Rome, Italy., Ceccanti M; Centro Riferimento Alcologico Regione Lazio, Sapienza University of Rome, Italy., Fiore M; Institute of Biochemistry and Cell Biology, Section of Neurobiology, National Research Council (IBBC-CNR), Rome, Italy.
Jazyk: angličtina
Zdroj: Journal of immunology research [J Immunol Res] 2020 Mar 23; Vol. 2020, pp. 6937154. Date of Electronic Publication: 2020 Mar 23 (Print Publication: 2020).
DOI: 10.1155/2020/6937154
Abstrakt: Down Syndrome (DS) is the most common chromosomal disorder. Although DS individuals are mostly perceived as characterized by some distinct physical features, cognitive disabilities, and cardiac defects, they also show important dysregulations of immune functions. While critical information is available for adults with DS, little literature is available on the neuroinflammation in prepubertal DS children. We aimed to evaluate in prepubertal DS children the serum levels of nerve growth factor (NGF) and brain-derived neurotrophic factor (BDNF), oxidative stress as free oxygen radicals defense (FORD), free oxygen radicals test (FORT), and cytokines playing key roles in neuroinflammation and oxidative processes as TNF- α , TGF- β , MCP-1, IL-1 α , IL-2, IL-6, IL-10, and IL-12. No differences were found in NGF between DS children and controls. However, BDNF was higher in DS subjects compared to controls. We also did not reveal changes in FORD and FORT. Quite interestingly, the serum of DS children disclosed a marked decrease in all analyzed cytokines with evident differences in serum cytokine presence between male and female DS children. In conclusion, the present study evidences in DS prepubertal children a disruption in the neurotrophins and immune system pathways.
Competing Interests: The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.
(Copyright © 2020 Luigi Tarani et al.)
Databáze: MEDLINE
Externí odkaz:
Nepřihlášeným uživatelům se plný text nezobrazuje