Quantification of tremor using consumer product accelerometry is feasible in patients with essential tremor and Parkinson's disease: a comparative study.

Autor: van Brummelen EMJ; 1Centre for Human Drug Research, Zernikedreef 8, Leiden, 2333 CL The Netherlands., Ziagkos D; 1Centre for Human Drug Research, Zernikedreef 8, Leiden, 2333 CL The Netherlands., de Boon WMI; 1Centre for Human Drug Research, Zernikedreef 8, Leiden, 2333 CL The Netherlands., Hart EP; 1Centre for Human Drug Research, Zernikedreef 8, Leiden, 2333 CL The Netherlands., Doll RJ; 1Centre for Human Drug Research, Zernikedreef 8, Leiden, 2333 CL The Netherlands., Huttunen T; 4Pharma Ltd, Turku, Finland., Kolehmainen P; Make Helsinki Oy, Helsinki, Finland., Groeneveld GJ; 1Centre for Human Drug Research, Zernikedreef 8, Leiden, 2333 CL The Netherlands.; 4Department of Anesthesiology, Leiden University Medical Center (LUMC), Leiden, The Netherlands.
Jazyk: angličtina
Zdroj: Journal of clinical movement disorders [J Clin Mov Disord] 2020 Apr 07; Vol. 7, pp. 4. Date of Electronic Publication: 2020 Apr 07 (Print Publication: 2020).
DOI: 10.1186/s40734-020-00086-7
Abstrakt: Background: To quantify pharmacological effects on tremor in patients with essential tremor (ET) or Parkinson's Disease (PD), laboratory-grade accelerometers have previously been used. Over the last years, consumer products such as smartphones and smartwatches have been increasingly applied to measure tremor in an easy way. However, it is unknown how the technical performance of these consumer product accelerometers (CPAs) compares to laboratory-grade accelerometers (LGA). This study was performed to compare the technical performance of CPAs with LGA to measure tremor in patients with Parkinson's Disease (PD) and essential tremor (ET).
Methods: In ten patients with PD and ten with ET, tremor peak frequency and corresponding amplitude were measured with 7 different CPAs (Apple iPhone 7, Apple iPod Touch 5, Apple watch 2, Huawei Nexus 6P, Huawei watch, mbientlabMetaWear (MW) watch, mbientlab MW clip) and compared to a LGA (Biometrics ACL300) in resting and extended arm position.
Results: Both in PD and ET patients, the peak frequency of CPAs did not significantly differ from the LGA in terms of limits of agreement. For the amplitude at peak frequency, only the iPhone and MW watch performed comparable to the LGA in ET patients, while in PD patients all methods performed comparable except for the iPod Touch and Huawei Nexus. Amplitude was higher when measured with distally-located CPAs (Clip, iPhone, iPod) compared with proximally-located CPAs (all watches). The variability between subjects was higher than within subjects for frequency (25.1% vs. 13.4%) and amplitude measurement (331% vs. 53.6%). Resting arm position resulted in lower intra-individual variability for frequency and amplitude (13.4 and 53.5%) compared to extended arm position (17.8 and 58.1%).
Conclusions: Peak frequencies of tremor could be measured with all tested CPAs, with similar performance as LGA. The amplitude measurements appeared to be driven by anatomical location of the device and can therefore not be compared. Our results show that the tested consumer products can be used for tremography, allowing at-home measurements, in particular in studies with a cross-over or intra-individual comparison design using the resting arm position.
Trial Registration: This trial was registered in the Dutch Competent Authority (CCMO) database with number NL60672.058.17 on May 30th 2017.
Competing Interests: Competing interestsCHDR developed a Centre for Human Drug Research app to capture accelerometer data for the iPod Touch 5, which was used in this study. PK was employed by MakeHelsinki Oy and TH was employed by 4Pharma Ltd. All other authors declare no competing interests.
(© The Author(s) 2020.)
Databáze: MEDLINE
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