Peripheral Blood Flow Changes to Cutaneous and Muscular Beds in Response to Acute Hookah Smoking.

Autor: Rezk-Hanna M; Smidt Heart Institute, Cedars-Sinai Medical Center, Los Angeles, California; School of Nursing, University of California, Los Angeles, Los Angeles, California. Electronic address: MRezk@ucla.edu., Nelson MD; Smidt Heart Institute, Cedars-Sinai Medical Center, Los Angeles, California; Department of Kinesiology, University of Texas at Arlington, Texas., Rader F; Smidt Heart Institute, Cedars-Sinai Medical Center, Los Angeles, California., Benowitz NL; Divsion of Clinical Pharmacology & Experimental Therapeutics, Departments of Medicine and Bioengineering & Therapeutic Sciences, University of California, San Francisco, San Francisco, California., Rosenberry R; Smidt Heart Institute, Cedars-Sinai Medical Center, Los Angeles, California; Department of Kinesiology, University of Texas at Arlington, Texas., Chang LC; Department of Biomathematics, David Geffen School of Medicine, University of California, Los Angeles, California, Los Angeles, California., Li N; Department of Biomathematics, David Geffen School of Medicine, University of California, Los Angeles, California, Los Angeles, California., Tashkin DP; Division of Pulmonary and Critical Care Medicine, Department of Medicine, David Geffen School of Medicine, University of California, Los Angeles, California, Los Angeles, California., Elashoff RM; Department of Biomathematics, David Geffen School of Medicine, University of California, Los Angeles, California, Los Angeles, California., Victor RG; Smidt Heart Institute, Cedars-Sinai Medical Center, Los Angeles, California.
Jazyk: angličtina
Zdroj: The American journal of cardiology [Am J Cardiol] 2020 Jun 01; Vol. 125 (11), pp. 1725-1731. Date of Electronic Publication: 2020 Mar 14.
DOI: 10.1016/j.amjcard.2020.02.042
Abstrakt: Hookah (waterpipe) smoking is a growing tobacco epidemic. Though perceived as a safer tobacco alternative, hookah smoke contains, in addition to tobacco combustion products, large amounts of charcoal combustion products-implicated in cardiovascular disease-from the burning charcoal used to heat the flavored tobacco. To date, little is known on the vascular effects of hookah smoking. The aim of this study was to characterize the peripheral circulatory response to acute hookah smoking in cutaneous and muscular beds. In 21 healthy young adult habitual hookah smokers who did not smoke cigarettes (age 24 ± 1 years, mean ± SE), we measured plasma nicotine, exhaled carbon monoxide, skin blood flow (laser Doppler velocimetry) and calf muscle blood flow (strain-gauge plethysmography) before and for up to 60 minutes after ad lib hookah smoking. In nine subjects, nonsmoking time-control studies were performed. Hookah smoking, which increased plasma nicotine by 5.8 ng/ml (from 0.6 ± 0.1 to 6.4 ± 1.3, p <0.001) and exhaled carbon monoxide by 27 ppm (from 2.7 ± 0.2 to 29.5 ± 2.2, p <0.001), decreased skin blood flow by 23% (20.1 ± 2.8 to 14.8 ± 1.9 units, p <0.001) and increased skeletal muscle blood flow by 34% (2.3 ± 0.1 to 2.9 ± 0.2 units, p = 0.010). These responses required more than one hour to recover after smoking cessation. All cardiovascular parameters were unchanged in the nonsmoking time-control studies. Although perceived to be innocuous, hookah smoking produces acute cutaneous vasoconstriction with skeletal muscle vasodilation, a dissociated pattern of peripheral blood flow responses that is characteristic of nicotine and carbon monoxide. In conclusion, these findings provide objective evidence to challenge the perception that hookah smoking is a safer tobacco alternative.
(Copyright © 2020 Elsevier Inc. All rights reserved.)
Databáze: MEDLINE
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