Effects and mechanisms of pyrethroids on male reproductive system.

Autor: Wang Q; School of Public Health, Xuzhou Medical University, 209 Tong-Shan Road, Xuzhou, 221004, Jiangsu, China., Shen JY; School of Public Health, Xuzhou Medical University, 209 Tong-Shan Road, Xuzhou, 221004, Jiangsu, China., Zhang R; School of Public Health, Xuzhou Medical University, 209 Tong-Shan Road, Xuzhou, 221004, Jiangsu, China., Hong JW; School of Public Health, Xuzhou Medical University, 209 Tong-Shan Road, Xuzhou, 221004, Jiangsu, China., Li Z; School of Public Health, Xuzhou Medical University, 209 Tong-Shan Road, Xuzhou, 221004, Jiangsu, China., Ding Z; School of Public Health, Xuzhou Medical University, 209 Tong-Shan Road, Xuzhou, 221004, Jiangsu, China., Wang HX; School of Public Health, Xuzhou Medical University, 209 Tong-Shan Road, Xuzhou, 221004, Jiangsu, China., Zhang JP; School of Public Health, Xuzhou Medical University, 209 Tong-Shan Road, Xuzhou, 221004, Jiangsu, China., Zhang MR; School of Public Health, Xuzhou Medical University, 209 Tong-Shan Road, Xuzhou, 221004, Jiangsu, China., Xu LC; School of Public Health, Xuzhou Medical University, 209 Tong-Shan Road, Xuzhou, 221004, Jiangsu, China. Electronic address: lichunxu2002@163.com.
Jazyk: angličtina
Zdroj: Toxicology [Toxicology] 2020 May 30; Vol. 438, pp. 152460. Date of Electronic Publication: 2020 Apr 08.
DOI: 10.1016/j.tox.2020.152460
Abstrakt: Synthetic pyrethroids are used as insecticides in agriculture and a variety of household applications worldwide. Pyrethroids are widely distributed in all environmental compartments and the general populations are exposed to pyrethroids through various routes. Pyrethroids have been identified as endocrine-disrupting chemicals (EDCs) which are responsible for the male reproductive impairments. The data confirm pyrethroids cause male reproductive damages. The insecticides exert the toxic effects on male reproductive system through various complex mechanisms including antagonizing androgen receptor (AR), inhibiting steroid synthesis, affecting the hypothalamic-pituitary-gonadal (HPG) axis, acting as estrogen receptor (ER) modulators and inducing oxidative stress. The mechanisms of male reproductive toxicity of pyrethroids involve multiple targets and pathways. The review will provide further insight into pyrethroid-induced male reproductive toxicity and mechanisms, which is crucial to preserve male reproductive health.
(Copyright © 2020 Elsevier B.V. All rights reserved.)
Databáze: MEDLINE
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