Association of IL-10 (rs1800872) and IL-4R (rs1805010) polymorphisms with cervical intraepithelial lesions and cervical carcinomas

Autor:	Duvlis S; Institute of Public Health, Department of Virology and Molecular Diagnostics, Skopje, Republic of North Macedonia;, Dabeski D; University Clinic for Gynecology and Obstetrics, University “Ss. Cyril and Methodius”, Skopje, Republic of North Macedonia, Noveski P; Research Centre for Genetic Engineering and Biotechnology ”Georgi D.Efremov”, Macedonian Academy of Science and Arts, Skopje, Republic of North Macedonia, Ivkovski L; Laboratory for Cytology and Histology, Histolab, Skopje, Republic of North Macedonia, Plaseska-Karanfilska D; Research Centre for Genetic Engineering and Biotechnology ”Georgi D.Efremov”, Macedonian Academy of Science and Arts, Skopje, Republic of North Macedonia
Jazyk:	angličtina
Zdroj:	Journal of B.U.ON. : official journal of the Balkan Union of Oncology [J BUON] 2020 Jan-Feb; Vol. 25 (1), pp. 132-140.
Abstrakt:	Purpose: Genetic characteristic of cytokines may influence cervical intraepithelial neoplasia (CIN) and cervical cancer (CCa) susceptibility. We analysed an association of IL-10-592 A/C, IL-4R I75VA/G polymorphisms with susceptibility to human papillomavirus (HPV) positive CIN and CCa. Methods: Using multiplex PCR- SNaPShot analysis, 134 cases (HPV positive CINs and CCa) and 113 controls (HPV negative NILM) were genotyped for these two cytokine variants. Results: Data analyzed using odds ratio (OR) and chisquare (x2) test showed that the frequency of CC of IL-10-592 genotype was significantly higher in cases (67.2%) than in controls (49.6%) [CC vs CA+AA; p=0.005, OR=2.08 (95%CI:1.24-3.49)] as well as the allelic frequency of major C allele (82.1%) in cases than in controls (72.6%) [p=0.01, OR=1.73 (95%CI: 1.13-2.66)]. Furthermore, AA genotype of IL-4RI75V had significantly lower frequency in CIN1 (25.0%) comparedwith CIN2+ group (30.8%) (p=0.03, OR=0.39, 95%CI: 0.14- 1.11) after the stratifications of the cases in low grade and high grade with CCa as separate groups. Conclusion: We concluded that IL-10-592 A/AA variant indicates a protective role in cervical cancer development and the GG genotype of IL-4RI75V conferred protection against progression of CIN1 to CIN2+ or CCa among women from Republic of North Macedonia.
Databáze:	MEDLINE
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