Triacylglycerol-Rich Oils of Marine Origin are Optimal Nutrients for Induction of Polyunsaturated Docosahexaenoic Acid Ester of Hydroxy Linoleic Acid (13-DHAHLA) with Anti-Inflammatory Properties in Mice.

Autor: Paluchova V; Institute of Physiology of the Czech Academy of Sciences, Videnska 1083, Prague, 14220, Czech Republic., Vik A; Department of Pharmacy, Section for Pharmaceutical Chemistry, University of Oslo, PO Box 1068, Blindern, Oslo, N-0316, Norway., Cajka T; Institute of Physiology of the Czech Academy of Sciences, Videnska 1083, Prague, 14220, Czech Republic., Brezinova M; Institute of Physiology of the Czech Academy of Sciences, Videnska 1083, Prague, 14220, Czech Republic., Brejchova K; Institute of Physiology of the Czech Academy of Sciences, Videnska 1083, Prague, 14220, Czech Republic., Bugajev V; Laboratory of Signal Transduction, Institute of Molecular Genetics of the Czech Academy of Sciences, Videnska 1083, Prague, 14220, Czech Republic., Draberova L; Laboratory of Signal Transduction, Institute of Molecular Genetics of the Czech Academy of Sciences, Videnska 1083, Prague, 14220, Czech Republic., Draber P; Laboratory of Signal Transduction, Institute of Molecular Genetics of the Czech Academy of Sciences, Videnska 1083, Prague, 14220, Czech Republic., Buresova J; Institute of Physiology of the Czech Academy of Sciences, Videnska 1083, Prague, 14220, Czech Republic., Kroupova P; Institute of Physiology of the Czech Academy of Sciences, Videnska 1083, Prague, 14220, Czech Republic., Bardova K; Institute of Physiology of the Czech Academy of Sciences, Videnska 1083, Prague, 14220, Czech Republic., Rossmeisl M; Institute of Physiology of the Czech Academy of Sciences, Videnska 1083, Prague, 14220, Czech Republic., Kopecky J; Institute of Physiology of the Czech Academy of Sciences, Videnska 1083, Prague, 14220, Czech Republic., Hansen TV; Department of Pharmacy, Section for Pharmaceutical Chemistry, University of Oslo, PO Box 1068, Blindern, Oslo, N-0316, Norway., Kuda O; Institute of Physiology of the Czech Academy of Sciences, Videnska 1083, Prague, 14220, Czech Republic.
Jazyk: angličtina
Zdroj: Molecular nutrition & food research [Mol Nutr Food Res] 2020 Jun; Vol. 64 (11), pp. e1901238. Date of Electronic Publication: 2020 Apr 22.
DOI: 10.1002/mnfr.201901238
Abstrakt: Scope: The docosahexaenoic acid ester of hydroxy linoleic acid (13-DHAHLA) is a bioactive lipid with anti-inflammatory properties from the family of fatty acid esters of hydroxy fatty acids (FAHFA).
Methods and Results: To explore the biosynthesis of 13-DHAHLA from dietary oils, C57BL/6N mice are gavaged for 8 days with various corn oil/marine oil mixtures containing the same amount of DHA. Plasma levels of omega-3 FAHFAs are influenced by the lipid composition of the mixtures but do not reflect the changes in bioavailability of polyunsaturated fatty acids in plasma. Triacylglycerol-bound DHA and linoleic acid serve as more effective precursors for 13-DHAHLA synthesis than DHA bound in phospholipids or wax esters. Both 13(S)- and 13(R)-DHAHLA inhibit antigen and PGE 2 -induced chemotaxis and degranulation of mast cells to a comparable extent and 13(S)-DHAHLA is identified as the predominant isomer in mouse adipose tissue.
Conclusion: Here, the optimal nutritional source of DHA is identified, which supports production of anti-inflammatory FAHFAs, as triacylglycerol-based marine oil and also reveals a possible role of triacylglycerols in the synthesis of FAHFA lipokines.
(© 2020 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.)
Databáze: MEDLINE
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