Toward Understanding Microbiome-Neuronal Signaling.

Autor:	Jameson KG; Department of Integrative Biology and Physiology, University of California, Los Angeles, Los Angeles, CA 90095, USA. Electronic address: kgjameson@g.ucla.edu., Olson CA; Department of Integrative Biology and Physiology, University of California, Los Angeles, Los Angeles, CA 90095, USA., Kazmi SA; Department of Integrative Biology and Physiology, University of California, Los Angeles, Los Angeles, CA 90095, USA., Hsiao EY; Department of Integrative Biology and Physiology, University of California, Los Angeles, Los Angeles, CA 90095, USA.
Jazyk:	angličtina
Zdroj:	Molecular cell [Mol Cell] 2020 May 21; Vol. 78 (4), pp. 577-583. Date of Electronic Publication: 2020 Apr 09.
DOI:	10.1016/j.molcel.2020.03.006
Abstrakt:	Host-associated microbiomes are emerging as important modifiers of brain activity and behavior. Metabolic, immune, and neuronal pathways are proposed to mediate communication across the so-called microbiota-gut-brain axis. However, strong mechanistic evidence, especially for direct signaling between microbes and sensory neurons, is lacking. Here, we discuss microbial regulation of short-chain fatty acids, neurotransmitters, as-yet-uncharacterized biochemicals, and derivatives of neuromodulatory drugs as important areas for assessing microbial interactions with the nervous system. Competing Interests: Declaration of Interests The authors declare no competing interests. (Copyright © 2020 Elsevier Inc. All rights reserved.)
Databáze:	MEDLINE
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