| Autor: |
Tahmasian M; Institute of Medical Science and Technology, Shahid Beheshti University, Tehran, Iran., Samea F; Institute of Medical Science and Technology, Shahid Beheshti University, Tehran, Iran., Khazaie H; Sleep Disorders Research Center, Kermanshah University of Medical Sciences, Kermanshah, Iran., Zarei M; Institute of Medical Science and Technology, Shahid Beheshti University, Tehran, Iran., Kharabian Masouleh S; Institute of Neuroscience and Medicine (INM-7: Brain and Behaviour), Research Centre Jülich, 52425, Jülich, Germany.; Institute of Systems Neuroscience, Heinrich Heine University Düsseldorf, 40225, Düsseldorf, Germany., Hoffstaedter F; Institute of Neuroscience and Medicine (INM-7: Brain and Behaviour), Research Centre Jülich, 52425, Jülich, Germany.; Institute of Systems Neuroscience, Heinrich Heine University Düsseldorf, 40225, Düsseldorf, Germany., Camilleri J; Institute of Neuroscience and Medicine (INM-7: Brain and Behaviour), Research Centre Jülich, 52425, Jülich, Germany.; Institute of Systems Neuroscience, Heinrich Heine University Düsseldorf, 40225, Düsseldorf, Germany., Kochunov P; Maryland Psychiatric Research Center, University of Maryland School of Medicine, Baltimore, MD, 21201, USA., Yeo BTT; Department of Electrical and Computer Engineering, Clinical Imaging Research Centre, N.1 Institute for Health and Memory Networks Program, National University of Singapore, Singapore, 119077, Singapore.; Athinoula A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Charlestown, MA, 02114, USA.; Centre for Sleep and Cognition, National University of Singapore, Singapore, 119077, Singapore.; NUS Graduate School for Integrative Sciences and Engineering, National University of Singapore, Singapore, 119077, Singapore., Eickhoff SB; Institute of Neuroscience and Medicine (INM-7: Brain and Behaviour), Research Centre Jülich, 52425, Jülich, Germany.; Institute of Systems Neuroscience, Heinrich Heine University Düsseldorf, 40225, Düsseldorf, Germany., Valk SL; Institute of Neuroscience and Medicine (INM-7: Brain and Behaviour), Research Centre Jülich, 52425, Jülich, Germany. svalk@fz-juelich.de.; Institute of Systems Neuroscience, Heinrich Heine University Düsseldorf, 40225, Düsseldorf, Germany. svalk@fz-juelich.de. |
| Abstrakt: |
Humans need about seven to nine hours of sleep per night. Sleep habits are heritable, associated with brain function and structure, and intrinsically related to well-being, mental, and physical health. However, the biological basis of the interplay of sleep and health is incompletely understood. Here we show, by combining neuroimaging and behavioral genetic approaches in two independent large-scale datasets (HCP (n = 1106), age range: 22-37, eNKI (n = 783), age range: 12-85), that sleep, mental, and physical health have a shared neurobiological basis in grey matter anatomy; and that these relationships are driven by shared genetic factors. Though local associations between sleep and cortical thickness were inconsistent across samples, we identified two robust latent components, highlighting the multivariate interdigitation of sleep, intelligence, BMI, depression, and macroscale cortical structure. Our observations provide a system-level perspective on the interrelation of sleep, mental, and physical conditions, anchored in grey-matter neuroanatomy. |
