Zinc at the crossroads of exercise and proteostasis.
| Autor: | Hernández-Camacho JD; Centro Andaluz de Biología del Desarrollo, CSIC-UPO-JA, Universidad Pablo de Olavide, Sevilla, 41013, Spain; CIBERER, Instituto de Salud Carlos III, Madrid, 28000, Spain., Vicente-García C; Centro Andaluz de Biología del Desarrollo, CSIC-UPO-JA, Universidad Pablo de Olavide, Sevilla, 41013, Spain., Parsons DS; Boston University School of Medicine, Boston, MA, 02118, USA., Navas-Enamorado I; Boston University School of Medicine, Boston, MA, 02118, USA. Electronic address: navas.enamorado.i@gmail.com. |
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| Jazyk: | angličtina |
| Zdroj: | Redox biology [Redox Biol] 2020 Aug; Vol. 35, pp. 101529. Date of Electronic Publication: 2020 Apr 01. |
| DOI: | 10.1016/j.redox.2020.101529 |
| Abstrakt: | Zinc is an essential element for all forms of life, and one in every ten human proteins is a zinc protein. Zinc has catalytic, structural and signalling functions and its correct homeostasis affects many cellular processes. Zinc deficiency leads to detrimental consequences, especially in tissues with high demand such as skeletal muscle. Zinc cellular homeostasis is tightly regulated by different transport and buffer protein systems. Specifically, in skeletal muscle, zinc has been found to affect myogenesis and muscle regeneration due to its effects on muscle cell activation, proliferation and differentiation. In relation to skeletal muscle, exercise has been shown to modulate zinc serum and urinary levels and could directly affect cellular zinc transport. The oxidative stress induced by exercise may provide the basis for the mild zinc deficiency observed in athletes and could have severe consequences on health and sport performance. Proteostasis is induced during exercise and zinc plays an essential role in several of the associated pathways. Competing Interests: Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper. (Copyright © 2020. Published by Elsevier B.V.) |
| Databáze: | MEDLINE |
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