Huntington's Disease: Genome-wide Neuroprotection Screening Goes Viral.
| Autor: | Lee CYD; Center for Neurobehavioral Genetics, Jane and Terry Semel Institute for Neuroscience & Human Behavior, David Geffen School of Medicine at UCLA, Los Angeles, CA 90095, USA; Department of Psychiatry and Biobehavioral Sciences, David Geffen School of Medicine at UCLA, Los Angeles, CA 90095, USA., Yang XW; Center for Neurobehavioral Genetics, Jane and Terry Semel Institute for Neuroscience & Human Behavior, David Geffen School of Medicine at UCLA, Los Angeles, CA 90095, USA; Department of Psychiatry and Biobehavioral Sciences, David Geffen School of Medicine at UCLA, Los Angeles, CA 90095, USA. Electronic address: xwyang@mednet.ucla.edu. |
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| Jazyk: | angličtina |
| Zdroj: | Neuron [Neuron] 2020 Apr 08; Vol. 106 (1), pp. 4-6. |
| DOI: | 10.1016/j.neuron.2020.03.020 |
| Abstrakt: | Forward genetic screen, typically performed in invertebrates or mammalian cell lines, has been instrumental in discovering genes essential for neural function. In this issue of Neuron, Wertz et al. (2020) demonstrate the first viral-mediated, genome-wide screen to identify neuroprotective genes in wild-type and Huntington's disease (HD) mouse brains. Competing Interests: Declaration of Interests X.W.Y. is on the Scientific Advisory Board of Mitokinin and was a paid consultant for Roche, Nuredis, and Voyager Therapeutics. (Copyright © 2020 Elsevier Inc. All rights reserved.) |
| Databáze: | MEDLINE |
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