The orphan nuclear receptor TLX: an emerging master regulator of cross-talk between microglia and neural precursor cells.
| Autor: | Lucassen PJ; Swammerdam Institute for Life Science, Center for Neuroscience, University of Amsterdam, Science Park 904, Amsterdam 1098 XH, The Netherlands., van Dam AM; Department of Anatomy and Neurosciences, Amsterdam University Medical Center, Vrije Universiteit Amsterdam, Amsterdam, The Netherlands., Kandel P; Baylor College of Medicine and Jan and Dan Duncan Neurological Research Institute at Texas Children's Hospital, Houston, TX, U.S.A., Bielefeld P; Swammerdam Institute for Life Science, Center for Neuroscience, University of Amsterdam, Science Park 904, Amsterdam 1098 XH, The Netherlands., Korosi A; Swammerdam Institute for Life Science, Center for Neuroscience, University of Amsterdam, Science Park 904, Amsterdam 1098 XH, The Netherlands., Fitzsimons CP; Swammerdam Institute for Life Science, Center for Neuroscience, University of Amsterdam, Science Park 904, Amsterdam 1098 XH, The Netherlands., Maletic-Savatic M; Baylor College of Medicine and Jan and Dan Duncan Neurological Research Institute at Texas Children's Hospital, Houston, TX, U.S.A. |
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| Jazyk: | angličtina |
| Zdroj: | Neuronal signaling [Neuronal Signal] 2019 Jun; Vol. 3 (2), pp. NS20180208. Date of Electronic Publication: 2019 Jun 06. |
| DOI: | 10.1042/NS20180208 |
| Abstrakt: | Neuroinflammation and neurogenesis have both been the subject of intensive investigation over the past 20 years. The sheer complexity of their regulation and their ubiquity in various states of health and disease have sometimes obscured the progress that has been made in unraveling their mechanisms and regulation. A recent study by Kozareva et al. ( Neuronal Signaling (2019) 3 ), provides evidence that the orphan nuclear receptor TLX is central to communication between microglia and neural precursor cells and could help us understand how inflammation, mediated by microglia, influences the development of new neurons in the adult hippocampus. Here, we put recent studies on TLX into the context of what is known about adult neurogenesis and microglial activation in the brain, along with the many hints that these processes must be inter-related. Competing Interests: The authors declare that there are no competing interests associated with the manuscript. (© 2019 The Author(s).) |
| Databáze: | MEDLINE |
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