Temozolomide in secondary prevention of HER2-positive breast cancer brain metastases.

Autor: Zimmer AS; Women's Malignancies Branch, National Cancer Institute, NIH, Bethesda, MD 20814, USA., Steinberg SM; Biostatistics & Data Management Section, National Cancer Institute, NIH, Bethesda, MD 20814, USA., Smart DD; Radiation Oncology Branch, National Cancer Institute, NIH, Bethesda, MD 20814, USA., Gilbert MR; Neuro-Oncology Branch, National Cancer Institute, NIH, Bethesda, MD 20814, USA., Armstrong TS; Neuro-Oncology Branch, National Cancer Institute, NIH, Bethesda, MD 20814, USA., Burton E; Neuro-Oncology Branch, National Cancer Institute, NIH, Bethesda, MD 20814, USA., Houston N; Women's Malignancies Branch, National Cancer Institute, NIH, Bethesda, MD 20814, USA., Biassou N; Neuro-Radiology, Clinical Center, NIH, Bethesda, MD 20814, USA., Gril B; Women's Malignancies Branch, National Cancer Institute, NIH, Bethesda, MD 20814, USA., Brastianos PK; Central Nervous System Metastases Program, Massachusetts General Hospital/Harvard Cancer Center Boston, MA 02114, USA., Carter S; Biostatistics and Computation Biology, Dana-Farber Cancer Institute, Boston, MA 02114, USA., Lyden D; Pediatric Hematology Oncology, Weill Cornell Medicine, New York, NY 10065, USA., Lipkowitz S; Women's Malignancies Branch, National Cancer Institute, NIH, Bethesda, MD 20814, USA., Steeg PS; Women's Malignancies Branch, National Cancer Institute, NIH, Bethesda, MD 20814, USA.
Jazyk: angličtina
Zdroj: Future oncology (London, England) [Future Oncol] 2020 May; Vol. 16 (14), pp. 899-909. Date of Electronic Publication: 2020 Apr 09.
DOI: 10.2217/fon-2020-0094
Abstrakt: Brain metastases occur in up to 25-55% of patients with metastatic HER2-positive breast cancer. Standard treatment has high rates of recurrence or progression, limiting survival and quality of life in most patients. Temozolomide (TMZ) is known to penetrate the blood-brain barrier and is US FDA approved for treatment of glioblastoma. Our group has demonstrated that low doses of TMZ administered in a prophylactic, metronomic fashion can significantly prevent development of brain metastases in murine models of breast cancer. Based on these findings, we initiated a secondary-prevention clinical trial with oral TMZ given to HER2-positive breast cancer patients with brain metastases after recent local treatment in combination with T-DM1 for systemic control of disease. Primary end point is freedom from new brain metastases at 1 year. (NCT03190967).
Databáze: MEDLINE