Link between ACE I/D Gene Polymorphism and Dyslipidemia in Diabetic Nephropathy: A Case-control Study from Hyderabad, India.

Autor: Mahwish UN; Department of Genetics, Osmania University, Hyderabad, Telangana, India., Ponnaluri KC; Department of Genetics, Osmania University, Hyderabad, Telangana, India., Heera B; Department of Zoology, Maulana Azad National Urdu University, Hyderabad, Telangana, India., Alavala SR; Department of Nephrology, Nizam's Institute of Medical Sciences, Hyderabad, Telangana, India., Devi KR; Department of Zoology, Osmania University, Hyderabad, Telangana, India., Raju SB; Department of Nephrology, Nizam's Institute of Medical Sciences, Hyderabad, Telangana, India., Latha GS; Department of Genetics, Osmania University, Hyderabad, Telangana, India., Jahan P; Department of Zoology, Maulana Azad National Urdu University, Hyderabad, Telangana, India.
Jazyk: angličtina
Zdroj: Indian journal of nephrology [Indian J Nephrol] 2020 Mar-Apr; Vol. 30 (2), pp. 77-84. Date of Electronic Publication: 2020 Feb 07.
DOI: 10.4103/ijn.IJN_244_18
Abstrakt: Introduction: Diabetic nephropathy (DN) is the commonest single cause of end-stage renal failure, and dyslipidemia is a critical risk factor in the occurrence of DN. In the light of recent reports emphasizing the importance of angiotensin I-converting enzyme (ACE) in the modulation of plasma lipids, we sought to evaluate the influence of ACE I/D gene polymorphism with dyslipidemia status among type 2 diabetic (T2D) patients with and without nephropathy in the genetic predisposition and the progression to DN.
Method: This study comprised of 600 subjects, which include patients with DN, T2D, and healthy controls (HC). Polymerase chain reaction based genotyping of ACE I/D polymorphism was performed and appropriate statistical analysis was done.
Results: Out of the 600 subjects, 20 (10%) of the HC, 73 (36.5%) of the T2D group, and 125 (62.5%) of the DN subjects had dyslipidemia. The D allele (0.62) and DD (42.5) genotype frequencies were higher in the DN group in comparison with T2D and HC ( P < 0.05). The genotypes also varied among patients with dyslipidemia (χ 2 5.04; P < 0.05) but not in the non-dyslipidemia group. Under the co-dominant model, DD genotype conferred a risk of 1.26 ( P < 0.001) toward DN, whereas the ID genotype offered protection from DN among the dyslipidemic subjects (OR = 0.05; P < 0.01). In addition, genotype-dependent difference was seen in the plasma lipid levels among study groups. A multiple logistic regression analysis revealed male gender, BMI, HbA1c, TG, HDL, and ACE DD genotype as independent risk factors for the development of DN.
Conclusion: The study showed a significant predisposing association of ACE DD genotype with DN and protective effect of ID genotype on DN in the dyslipidemia subgroup.
Competing Interests: There are no conflicts of interest.
(Copyright: © 2020 Indian Journal of Nephrology.)
Databáze: MEDLINE
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