Hydrogen sulfide attenuates diabetic neuropathic pain through NO/cGMP/PKG pathway and μ-opioid receptor.
| Autor: | Li H; Medical Management Department, Shandong Cancer Hospital and Institute, Shandong First Medical University and Shandong Academy of Medical Sciences, Shandong 250117, China., Liu S; Department of Aviation Medicine, Naval Medical Institute, Second Military Medical University, Shanghai 200433, China., Wang Z; Pre Hospital Emergency Department, Shandong Otolaryngology Hospital Affiliated to Shandong University (West Hospital of Shandong Provincial Hospital), Shandong 250117, China., Zhang Y; Department of Anesthesiology, Shandong Cancer Hospital and Institute, Shandong First Medical University and Shandong Academy of Medical Sciences, Shandong 250117, China., Wang K; Department of Anesthesiology, Shandong Cancer Hospital and Institute, Shandong First Medical University and Shandong Academy of Medical Sciences, Shandong 250117, China. |
|---|---|
| Jazyk: | angličtina |
| Zdroj: | Experimental biology and medicine (Maywood, N.J.) [Exp Biol Med (Maywood)] 2020 May; Vol. 245 (9), pp. 823-834. Date of Electronic Publication: 2020 Apr 08. |
| DOI: | 10.1177/1535370220918193 |
| Abstrakt: | Impact Statement: There are currently approximately 425 million diabetic patients worldwide, of which approximately 90% of patients with diabetes suffer from neuropathy. Diabetic neuropathic pain (DNP) is a common complication of diabetic neuropathy. Nearly half of the patients hospitalized with diabetes have pain symptoms or symptoms related to neurological injury, and the incidence increases with age and diabetic duration. Anti-DNP analgesics have either limited therapeutic effects or serious side effects or lack of clinical trials, which has limited their application. Physiopathological mechanisms and treatment of DNP remain a significant challenge. The present confirmed that inhalation of H |
| Databáze: | MEDLINE |
| Externí odkaz: |
|