Tumor-to-Tumor Metastasis of Multiple Meningiomas and Clear Cell Renal Cell Carcinoma Metastasis as First Clinical Appearance of Kidney Cancer: A Case Report and Analysis.
| Autor: | Dietterle J; Department of Neurosurgery, University Hospital Leipzig, Leipzig, Germany., Frydrychowicz C; Section of Neuropathology, Department of Diagnostic Medicine, University Hospital Leipzig, Leipzig, Germany., Müller W; Section of Neuropathology, Department of Diagnostic Medicine, University Hospital Leipzig, Leipzig, Germany., Hoffmann KT; Section of Neuroradiology, Department of Diagnostic Medicine, University Hospital Leipzig, Leipzig, Germany., Jähne K; Department of Neurosurgery, University Hospital Leipzig, Leipzig, Germany., Meixensberger J; Department of Neurosurgery, University Hospital Leipzig, Leipzig, Germany. |
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| Jazyk: | angličtina |
| Zdroj: | Journal of neurological surgery reports [J Neurol Surg Rep] 2020 Jan; Vol. 81 (1), pp. e10-e14. Date of Electronic Publication: 2020 Mar 31. |
| DOI: | 10.1055/s-0040-1708846 |
| Abstrakt: | Background Meningioma accounts for more than 35% of all diagnosed brain tumors of the central nervous system and, moreover, it is the most common benign recipient of tumor-to-tumor metastasis. Several cases with tumor-to-meningioma metastasis by breast, lung, and intestinal cancer have been described before. Case description The case of a patient with a longstanding history of multiple meningiomas ( n = 4) that suddenly became symptomatic and progressive in size is presented. Following extirpation of the two largest meningiomas, a histological examination revealed two separate tumor-to-meningioma metastases of clear cell renal cell carcinoma that was undiagnosed before. Post-surgical computed tomography scan then confirmed tumor-suspect lesions in both kidneys. After recovery and rehabilitation, adjuvant radio-chemo-therapy was applied according to protocols for kidney cancer. No other tumor-to-tumor-suspect event occurred since then for the remaining two meningiomas. Conclusion Review of literature and our case strengthens the idea of meningioma as a favorable premetastatic niche. Considering that the patient lived with a stable disease for many years, a sudden progress of tumor size in association with neurological deterioration was highly suspected for malign involvement, including the possibility of tumor-to-tumor metastasis. Physicians should be aware about this phenomenon and treat patients accordingly to the underlying disease. Competing Interests: Conflict of Interest Authors declare that they have no conflict of interest. |
| Databáze: | MEDLINE |
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