Nutritional regulation of glucose metabolism-related genes in the emerging teleost model Mexican tetra surface fish: a first exploration.

Autor:	Marandel L; INRAE, Université de Pau & Pays de l'Adour, E2S UPPA, UMR1419 Nutrition Metabolism and Aquaculture, Aquapôle, 64310 Saint-Pée-sur-Nivelle, France., Plagnes-Juan E; INRAE, Université de Pau & Pays de l'Adour, E2S UPPA, UMR1419 Nutrition Metabolism and Aquaculture, Aquapôle, 64310 Saint-Pée-sur-Nivelle, France., Marchand M; INRAE, Université de Pau & Pays de l'Adour, E2S UPPA, UMR1419 Nutrition Metabolism and Aquaculture, Aquapôle, 64310 Saint-Pée-sur-Nivelle, France., Callet T; INRAE, Université de Pau & Pays de l'Adour, E2S UPPA, UMR1419 Nutrition Metabolism and Aquaculture, Aquapôle, 64310 Saint-Pée-sur-Nivelle, France., Dias K; INRAE, Université de Pau & Pays de l'Adour, E2S UPPA, UMR1419 Nutrition Metabolism and Aquaculture, Aquapôle, 64310 Saint-Pée-sur-Nivelle, France., Terrier F; INRAE, Université de Pau & Pays de l'Adour, E2S UPPA, UMR1419 Nutrition Metabolism and Aquaculture, Aquapôle, 64310 Saint-Pée-sur-Nivelle, France., Père S; Paris-Saclay Institute of Neuroscience, CNRS UMR9197, Université Paris-Saclay, Avenue de la terrasse, Gif-sur-Yvette, France., Vernier L; Paris-Saclay Institute of Neuroscience, CNRS UMR9197, Université Paris-Saclay, Avenue de la terrasse, Gif-sur-Yvette, France., Panserat S; INRAE, Université de Pau & Pays de l'Adour, E2S UPPA, UMR1419 Nutrition Metabolism and Aquaculture, Aquapôle, 64310 Saint-Pée-sur-Nivelle, France., Rétaux S; Paris-Saclay Institute of Neuroscience, CNRS UMR9197, Université Paris-Saclay, Avenue de la terrasse, Gif-sur-Yvette, France.
Jazyk:	angličtina
Zdroj:	Royal Society open science [R Soc Open Sci] 2020 Feb 26; Vol. 7 (2), pp. 191853. Date of Electronic Publication: 2020 Feb 26 (Print Publication: 2020).
DOI:	10.1098/rsos.191853
Abstrakt:	Astyanax mexicanus has gained importance as a laboratory model organism for evolutionary biology. However, little is known about its intermediary metabolism, and feeding regimes remain variable between laboratories holding this species. We thus aimed to evaluate the intermediary metabolism response to nutritional status and to low (NC) or high (HC) carbohydrate diets in various organs of the surface-dwelling form of the species. As expected, glycaemia increased after feeding. Fish fed the HC diet had higher glycaemia than fish fed the NC diet, but without displaying hyperglycaemia, suggesting that carbohydrates are efficiently used as an energy source. At molecular level, only fasn ( Fatty Acid Synthase ) transcripts increased in tissues after refeeding, suggesting an activation of lipogenesis. On the other hand, we monitored only moderate changes in glucose-related transcripts. Most changes observed were related to the nutritional status, but not to the NC versus HC diet. Such a metabolic pattern is suggestive of an omnivorous-related metabolism, and this species, at least at adult stage, may adapt to a fish meal-substituted diet with high carbohydrate content and low protein supply. Investigation to identify molecular actors explaining the efficient use of such a diet should be pursued to deepen our knowledge on this species. Competing Interests: The authors declare that there are no conflicts/competing of interests. (© 2020 The Authors.)
Databáze:	MEDLINE
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