| Autor: |
Toro-González M; Department of Mechanical and Nuclear Engineering, Virginia Commonwealth University, Richmond, VA, USA. torogonzalezm@vcu.edu jvrojas@vcu.edu., Copping R, Mirzadeh S, Rojas JV |
| Jazyk: |
angličtina |
| Zdroj: |
Journal of materials chemistry. B [J Mater Chem B] 2018 Dec 21; Vol. 6 (47), pp. 7985-7997. Date of Electronic Publication: 2018 Nov 20. |
| DOI: |
10.1039/c8tb02173b |
| Abstrakt: |
Gadolinium vanadate nanoparticles (NPs) doped with europium, in concentrations between 5-40%, were synthesized via an aqueous route to prove their multimodal imaging functionalities and their performance as radionuclide carriers for targeted alpha therapy. Core-shell Gd 0.8 Eu 0.2 VO 4 NPs were doped with the α-emitting actinium-225 to assess the in vitro retention of 225 Ac and its decay daughters; francium-221 and bismuth-213. Gd 0.8 Eu 0.2 VO 4 core-shell NPs were obtained using a precipitation synthesis route having a tetragonal system, a spherical morphology, and a uniform particle size distribution. Gd 0.8 Eu 0.2 VO 4 core-shell NPs displayed the characteristic intense emission at 618 nm (red) and paramagnetic behavior of Eu and Gd cations, respectively. Partial retention of radionuclides was obtained with Gd 0.8 Eu 0.2 VO 4 core NPs, while deposition of two nonradioactive Gd 0.8 Eu 0.2 VO 4 shells significantly decreased the leakage of both 225 Ac and 221 Fr. The luminescence and magnetic functionalities as well as radionuclide retention capabilities of Gd 0.8 Eu 0.2 VO 4 core-shell NPs demonstrate their potential for biomedical applications. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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