A focus on the association of Apol1 with kidney disease in children.

Autor:	Ekulu PM; Department of Development and Regeneration, KU Leuven, Leuven, Belgium. drmfutu@yahoo.fr.; Division of Nephrology, Department of Pediatrics, Faculty of Medicine, University Hospital of Kinshasa, University of Kinshasa, Kinshasa, Democratic Republic of Congo. drmfutu@yahoo.fr., Nkoy AB; Division of Nephrology, Department of Pediatrics, Faculty of Medicine, University Hospital of Kinshasa, University of Kinshasa, Kinshasa, Democratic Republic of Congo., Adebayo OC; Department of Development and Regeneration, KU Leuven, Leuven, Belgium., Kazadi OK; Division of Nephrology, Department of Pediatrics, Faculty of Medicine, University Hospital of Kinshasa, University of Kinshasa, Kinshasa, Democratic Republic of Congo., Aloni MN; Division of Nephrology, Department of Pediatrics, Faculty of Medicine, University Hospital of Kinshasa, University of Kinshasa, Kinshasa, Democratic Republic of Congo., Arcolino FO; Department of Development and Regeneration, KU Leuven, Leuven, Belgium., Ngiyulu RM; Division of Nephrology, Department of Pediatrics, Faculty of Medicine, University Hospital of Kinshasa, University of Kinshasa, Kinshasa, Democratic Republic of Congo., Gini JE; Division of Nephrology, Department of Pediatrics, Faculty of Medicine, University Hospital of Kinshasa, University of Kinshasa, Kinshasa, Democratic Republic of Congo., Lepira FB; Division of Nephrology, Department of Internal Medicine, Faculty of Medicine, University Hospital of Kinshasa, University of Kinshasa, Kinshasa, Democratic Republic of Congo., Van den Heuvel LP; Department of Development and Regeneration, KU Leuven, Leuven, Belgium.; Department of Pediatric Nephrology, Radboud University Medical Centre, Nijmegen, Netherlands., Levtchenko EN; Department of Pediatric Nephrology & Department of Development and Regeneration, University Hospital Leuven, KU Leuven, Leuven, Belgium.
Jazyk:	angličtina
Zdroj:	Pediatric nephrology (Berlin, Germany) [Pediatr Nephrol] 2021 Apr; Vol. 36 (4), pp. 777-788. Date of Electronic Publication: 2020 Apr 06.
DOI:	10.1007/s00467-020-04553-z
Abstrakt:	Individuals of African origin have an increased risk of developing various progressive chronic kidney diseases (CKD). This risk has been attributed to genetic variants (G1, G2) in apolipoprotein-L1 (APOL1) gene. In the pediatric population, especially in children affected by sickle cell disease (SCD), by human immunodeficiency virus (HIV), or with various glomerular diseases, APOL1 risk variants have been associated with the development of hypertension, albuminuria, and more rapid decline of kidney function. The present review focuses on existing APOL1-related epidemiological data in children with CKD. It also includes data from studies addressing racial disparities in CKD, the APOL1-related innate immunity, and the relationship between APOL1 and CKD and pathogenic pathways mediating APOL1-related kidney injury.
Databáze:	MEDLINE
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