64 Cu-ATSM and 99m Tc(CO) 3 -DCM20 potential in the early detection of rheumatoid arthritis.
Autor: | Dam TT; Department of Diagnostic Radiology and Nuclear Medicine, Gunma University Graduate School of Medicine, Maebashi, Japan., Hanaoka H; Department of Bioimaging Information Analysis, Gunma University Graduate School of Medicine, Maebashi, Japan., Nakajima T; Department of Diagnostic Radiology and Nuclear Medicine, Gunma University Graduate School of Medicine, Maebashi, Japan., Yamaguchi A; Department of Bioimaging Information Analysis, Gunma University Graduate School of Medicine, Maebashi, Japan.; Texas Therapeutics Institute, The Brown Foundation Institute of Molecular Medicine, The University of Texas Health Science Center at Houston, TX, USA., Okamura K; Deparment of Orthopaedic Surgery, Gunma University Graduate School of Medicine, Maebashi, Japan., Chikuda H; Deparment of Orthopaedic Surgery, Gunma University Graduate School of Medicine, Maebashi, Japan., Tsushima Y; Department of Diagnostic Radiology and Nuclear Medicine, Gunma University Graduate School of Medicine, Maebashi, Japan.; Research Program for Diagnostic and Molecular Imaging, Division of Integrated Oncology Research, Gunma University Initiative for Advanced Research (GIAR), Gunma University Graduate School of Medicine, Maebashi, Japan. |
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Jazyk: | angličtina |
Zdroj: | Modern rheumatology [Mod Rheumatol] 2021 Mar; Vol. 31 (2), pp. 350-356. Date of Electronic Publication: 2020 Apr 23. |
DOI: | 10.1080/14397595.2020.1751945 |
Abstrakt: | Objectives: Molecular imaging constitutes a promising technique for the early detection of rheumatoid arthritis (RA). Macrophages and hypoxia play significant roles in inflamed synovium. In the present study, we evaluated the efficacy of radiopharmaceuticals that target macrophage mannose receptors ( 99m Tc-labeled mannosylated dextran or 99m Tc(CO) Methods: CIA model was developed in DBA/1 mice, and the clinical score for arthritis was visually assessed on a regular basis. Two biodistribution studies were performed in a paired-labeled format using 2-deoxy-2- 18 F-fluoro-D-glucose ( 18 F-FDG) as a reference: (1) 99m Tc(CO) Results: The accumulation levels of 99m Tc(CO) Conclusion: These results suggest the potential usefulness of 99m Tc(CO) |
Databáze: | MEDLINE |
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