Brain magnetic resonance imaging features in multiple sclerosis and neuromyelitis optica spectrum disorders patients with or without aquaporin-4 antibody in a Latin American population.

Autor: Silveira F; Servicio de Neurología, Hospital Italiano de Buenos Aires, Argentina, Gascón 450, Buenos Aires C 1181 Argentina. Electronic address: facundo.silveira@hospitalitaliano.org.ar., Pappolla A; Servicio de Neurología, Hospital Italiano de Buenos Aires, Argentina, Gascón 450, Buenos Aires C 1181 Argentina., Sánchez F; Centro de Esclerosis Múltiple de Buenos Aires (CEMBA), Hospital Italiano de Buenos Aires, Argentina., Marques VD; Department of Neurosciences and Behavioral Sciences, Hospital das Clínicas, Ribeirão Preto Medical School, University of São Paulo, São Paulo, Brazil., de Castillo IS; Neurology Department, Hospital Universitario de Maracaibo, Maracaibo, Venezuela., Tkachuk V; Neuroimmunology Unit, Department of Neurology, Hospital de Clínicas 'José de San Martín', Buenos Aires, Argentina., Caride A; Neuroimmunology Unit, Department of Neuroscience, Hospital Alemán, Buenos Aires, Argentina., Castillo MC; Neurology Department, Hospital Universitario de Maracaibo, Maracaibo, Venezuela., Cristiano E; Centro de Esclerosis Múltiple de Buenos Aires (CEMBA), Hospital Italiano de Buenos Aires, Argentina., Cruz CA; Department of Neurosciences and Behavioral Sciences, Hospital das Clínicas, Ribeirão Preto Medical School, University of São Paulo, São Paulo, Brazil., Diégues Serva GB; Department of Neurosciences and Behavioral Sciences, Hospital das Clínicas, Ribeirão Preto Medical School, University of São Paulo, São Paulo, Brazil., Dos Santos AC; Department of Neurosciences and Behavioral Sciences, Hospital das Clínicas, Ribeirão Preto Medical School, University of São Paulo, São Paulo, Brazil., Moreira CL; Department of Neurosciences and Behavioral Sciences, Hospital das Clínicas, Ribeirão Preto Medical School, University of São Paulo, São Paulo, Brazil., López PA; Neuroimmunology Unit, Department of Neuroscience, Hospital Alemán, Buenos Aires, Argentina., Patrucco L; Servicio de Neurología, Hospital Italiano de Buenos Aires, Argentina, Gascón 450, Buenos Aires C 1181 Argentina., Molina O; Neurology Department, Hospital Universitario de Maracaibo, Maracaibo, Venezuela., Pettinicchi JP; Neuroimmunology Unit, Department of Neuroscience, Hospital Alemán, Buenos Aires, Argentina., Carnero Contentti E; Neuroimmunology Unit, Department of Neuroscience, Hospital Alemán, Buenos Aires, Argentina., Rojas JI; Servicio de Neurología, Hospital Italiano de Buenos Aires, Argentina, Gascón 450, Buenos Aires C 1181 Argentina.
Jazyk: angličtina
Zdroj: Multiple sclerosis and related disorders [Mult Scler Relat Disord] 2020 Jul; Vol. 42, pp. 102049. Date of Electronic Publication: 2020 Mar 14.
DOI: 10.1016/j.msard.2020.102049
Abstrakt: Introduction: There is scarce evidence comparing the behavior in magnetic resonance (MRI) between positive and negative aquaporin-4 antibody neuromyelitis optica spectrum disorders (P-NMOSD and NNMOSD, respectively). The aim of this study was to describe and compare MRI features through a quantitative and qualitative analysis between P-NMOSD and NNMOSD patients in a cohort from Latin American (LATAM) patients.
Methods: We retrospectively reviewed the MRI and medical records of NMOSD patients as defined by the 2015 validated diagnostic criteria, and with at least 3 years of follow-up from disease onset (first symptom). We included patients from Argentina, Brazil and Venezuela. To be included, NMOSD patients must have had AQP4-ab status measured by a cell-based assay. Brain MRIs were obtained for each participant at disease onset and every 12 months for 3 years. Demographics, clinical and MRI variables (T2 lesion volume [T2LV], lesion distribution, cortical thickness [CT] and percentage of brain volume loss [PBVL]) were analyzed and compared between groups (P-NMOSD; NNMOSD) at disease onset and follow-up. A multiple sclerosis (MS) control group of patients was also included.
Results: We included 24 P-NMOSD, 15 NNMOSD and 35 MS patients. No differences in age, gender and follow-up time were observed between groups. Nor were differences found in lesion distribution at disease onset or in brain volumes during follow-up between P-NMOSD and NNMOSD patients (T2LV = 0.43, CT = 0.12, PBVL p = 0.45). Significant differences were observed in lesion distribution at disease onset, as well as in brain volumes during follow-up between NMOSD and MS (T2LV = p<0.001, CT = p<0.001, PBVL p = 0.01).
Conclusion: Different MRI features were observed between MS and NMOSD. However, no quantitative nor qualitative differences were observed between P-NMOSD and NNMOSD, not allowing us to differentiate NMOSD conditions by MRI.
Competing Interests: Declaration of Competing Interest None
(Copyright © 2020 Elsevier B.V. All rights reserved.)
Databáze: MEDLINE
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