| Autor: |
Nguyen HD; Cancer Division, Burnett School of Biomedical Sciences, University of Central Florida; hung.nguyen@ucf.edu., Huong PT; Department of Biochemistry, Hanoi University of Pharmacy., Hossack K; Cancer Division, Burnett School of Biomedical Sciences, University of Central Florida., Gurshaney S; Cancer Division, Burnett School of Biomedical Sciences, University of Central Florida., Ezhakunnel K; Cancer Division, Burnett School of Biomedical Sciences, University of Central Florida., Huynh TH; Cancer Division, Burnett School of Biomedical Sciences, University of Central Florida., Alvarez AM; Cancer Division, Burnett School of Biomedical Sciences, University of Central Florida., Le NT; Center for Cardiovascular Regeneration, Department of Cardiovascular Sciences, Houston Methodist Research Institute., Luu HN; Department of Epidemiology, University of Pittsburgh Graduate School of Public Health; Division of Cancer Control and Population Sciences, University of Pittsburgh Medical Center, Hillman Cancer Center. |
| Abstrakt: |
Allogeneic bone marrow transplantation (BMT) is an effective therapy for hematological malignancies due to the graft-versus-leukemia (GVL) effect to eradicate tumors. However, its application is limited by the development of graft-versus-host disease (GVHD), a major complication of BMT. GVHD is evoked when T-cells in the donor grafts recognizealloantigen expressed by recipient cells and mount unwanted immunological attacks against recipient healthy tissues. Thus, traditional therapies are designed to suppress donor T-cell alloreactivity. However, these approaches substantially impair the GVL effect so that the recipient's survival is not improved. Understanding the effects of therapeutic approaches on BMT, GVL, and GVHD, is thus essential. Due to the antigen-presenting and cytokine-secreting capacities to stimulate donor T-cells, recipient dendritic cells (DCs) play a significant role in the induction of GVHD. Therefore, targeting recipient DCs becomes a potential approach for controlling GVHD. This work provides a description of a novel BMT platform to investigate how host DCs regulate GVH and GVL responses after transplantation. Also presented is an effective BMT model to study the biology of GVHD and GVL after transplantation. |
