The cutaneous microbiome in hospitalized patients with pressure ulcers.

Autor: de Wert LA; Department of Surgery, Maastricht University Medical Centre, Maastricht, The Netherlands.; NUTRIM School for Nutrition and Translational Metabolism, Maastricht University, Maastricht, The Netherlands., Rensen SS; Department of Surgery, Maastricht University Medical Centre, Maastricht, The Netherlands.; NUTRIM School for Nutrition and Translational Metabolism, Maastricht University, Maastricht, The Netherlands., Soons Z; Department of Surgery, Maastricht University Medical Centre, Maastricht, The Netherlands. zita.soons@maastrichtuniversity.nl.; NUTRIM School for Nutrition and Translational Metabolism, Maastricht University, Maastricht, The Netherlands. zita.soons@maastrichtuniversity.nl., Poeze M; Department of Surgery, Maastricht University Medical Centre, Maastricht, The Netherlands.; NUTRIM School for Nutrition and Translational Metabolism, Maastricht University, Maastricht, The Netherlands., Bouvy ND; Department of Surgery, Maastricht University Medical Centre, Maastricht, The Netherlands.; NUTRIM School for Nutrition and Translational Metabolism, Maastricht University, Maastricht, The Netherlands., Penders J; NUTRIM School for Nutrition and Translational Metabolism, Maastricht University, Maastricht, The Netherlands.; Department of Medical Microbiology, Maastricht University Medical Centre, Maastricht, The Netherlands.; CAPHRI School for Public Health and Primary care, Maastricht University Medical Centre, Maastricht, The Netherlands.
Jazyk: angličtina
Zdroj: Scientific reports [Sci Rep] 2020 Apr 06; Vol. 10 (1), pp. 5963. Date of Electronic Publication: 2020 Apr 06.
DOI: 10.1038/s41598-020-62918-8
Abstrakt: This study investigated whether there are differences in the composition of the cutaneous microbiome of the unaffected skin between patients with pressure ulcers compared with those without pressure ulcers. The cutaneous microbiome of the unaffected skin of 15 patients with sacral pressure ulcers compared to 15 patients without pressure ulcers was analysed. It demonstrated that the inter-individual variation in skin microbiota of patients with pressure ulcers was significantly higher (P = 0.01). The abundance of 23 species was significantly different with Staphylococcus aureus and unclassified Enterococcus the most abundant species in patients with pressure ulcers. Random Forest models showed that eight species were associated with pressure ulcers occurrence in 81% of the patients. A subset of four species gave the strongest interaction. The presence of unclassified Enterococcus had the highest association with pressure ulcer occurrence. This study is the first to demonstrate that the cutaneous microbiome is altered in patients with pressure ulcers.
Databáze: MEDLINE
Externí odkaz:
Nepřihlášeným uživatelům se plný text nezobrazuje