Inactivation of endopeduncular nucleus impaired fear conditioning and hippocampal synaptic plasticity in rats.

Autor: Chen Y; Department of Basic Medicine, Medical School, Kunming University of Science and Technology, Kunming, Yunnan 650550, China., Kang N; Department of Basic Medicine, Medical School, Kunming University of Science and Technology, Kunming, Yunnan 650550, China., Gu J; Department of Basic Medicine, Medical School, Kunming University of Science and Technology, Kunming, Yunnan 650550, China., Chu B; Department of Basic Medicine, Medical School, Kunming University of Science and Technology, Kunming, Yunnan 650550, China., Luo L; Department of Basic Medicine, Medical School, Kunming University of Science and Technology, Kunming, Yunnan 650550, China., An Y; Department of Basic Medicine, Medical School, Kunming University of Science and Technology, Kunming, Yunnan 650550, China., Yang F; School of Life Science and Medicine, Dalian University of Technology, China., Cao J; Laboratory of Ecology and Evolutionary Biology, State Key Laboratory for Conservation and Utilization of Bio-Resources in Yunnan, Yunnan University, Kunming, Yunnan 650091, China., Zhang J; Department of Basic Medicine, Medical School, Kunming University of Science and Technology, Kunming, Yunnan 650550, China. Electronic address: zhangjc@kmust.edu.cn.
Jazyk: angličtina
Zdroj: Neurobiology of learning and memory [Neurobiol Learn Mem] 2020 Sep; Vol. 173, pp. 107224. Date of Electronic Publication: 2020 Apr 01.
DOI: 10.1016/j.nlm.2020.107224
Abstrakt: The internal globus pallidus (GPi) is one part of basal ganglion nucleuses which play fundamental role in motor function. Recent studies indicated that GPi could modulate emotional processing and learning, but the possible mechanism remains still unknown. In this study, the effects of endopeduncular nucleus (EP, a rodent homolog of GPi) on fear conditioning were tested in rats. GABA A receptor agonist muscimol was bilaterally delivered into the EP 15 min before or immediately after fear conditioning in rats. We found that EP inactivation impaired the acquisition but not consolidation of fear memory in rats. Furthermore, the long-term potentiation (LTP) in hippocampal CA1 area was impaired, and the learning related phosphorylation of α-amino-3-hydroxy-5-methyl-4-isoxazole-propionic acid receptor (AMPAR) subunit 1 (GluA1) at the Ser845 site in hippocampus was decreased in muscimol treated group. These results demonstrated that dysfunction of EP impaired hippocampal dependent learning and memory in rats.
Competing Interests: Declaration of Competing Interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.
(Copyright © 2020. Published by Elsevier Inc.)
Databáze: MEDLINE
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