The Role of Dietary Advanced Glycation End Products in Metabolic Dysfunction.

Autor: Sergi D; Nutrition and Health Substantiation Group, Nutrition and Health Program, Health and Biosecurity, Commonwealth Scientific and Industrial Research Organisation (CSIRO), Adelaide, SA, 5000, Australia.; Adelaide Medical School, The University of Adelaide, Adelaide, SA, 5000, Australia., Boulestin H; Rowett Institute, University of Aberdeen, Aberdeen, AB25 2ZD, UK., Campbell FM; Rowett Institute, University of Aberdeen, Aberdeen, AB25 2ZD, UK., Williams LM; Rowett Institute, University of Aberdeen, Aberdeen, AB25 2ZD, UK.
Jazyk: angličtina
Zdroj: Molecular nutrition & food research [Mol Nutr Food Res] 2021 Jan; Vol. 65 (1), pp. e1900934. Date of Electronic Publication: 2020 Apr 20.
DOI: 10.1002/mnfr.201900934
Abstrakt: Advanced glycation end products (AGEs) are a heterogeneous group of molecules produced, non-enzymatically, from the interaction between reducing sugars and the free amino groups of proteins, nucleic acids, and lipids. AGEs are formed as a normal consequence of metabolism but can also be absorbed from the diet. They have been widely implicated in the complications of diabetes affecting cardiovascular health, the nervous system, eyes, and kidneys. Increased levels of AGEs are also detrimental to metabolic health and may contribute to the metabolic abnormalities induced by the Western diet, which is high in processed foods and represents a significant source of AGEs. While increased AGE levels are a consequence of diabetic hyperglycaemia, AGEs themselves activate signaling pathways, which compromise insulin signaling and pancreatic β-cell function, thus, contributing to the development of type 2 diabetes mellitus (T2DM). Furthermore, AGEs may also contribute to the obesogenic effects of the Western diet by promoting hypothalamic inflammation and disrupting the central control of energy balance. Here, the role of dietary AGEs in metabolic dysfunction is reviewed with a focus on the mechanisms underpinning their detrimental role in insulin resistance, pancreatic β-cell dysfunction, hypothalamic control of energy balance, and the pathogenesis of T2DM and obesity.
(© 2020 The Authors. Molecular Nutrition & Food Research published by Wiley-VCH Verlag GmbH & Co. KGaA.)
Databáze: MEDLINE
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