BMI, physical activity, and breast cancer subtype in white, black, and Sea Island breast cancer survivors.

Autor:	Ford ME; Professor, Department of Public Health Sciences, Medical University of South Carolina, Charleston, SC, United States; Associate Director, Population Sciences and Cancer Disparities, Hollings Cancer Center, Medical University of South Carolina, Charleston, SC United States; SmartState Endowed Chair in Cancer Disparities Research, South Carolina State University, Orangeburg, SC, United States. Electronic address: fordmar@musc.edu., Bauza CE; Professor, Department of Public Health Sciences, Medical University of South Carolina, Charleston, SC, United States., Findlay VJ; Hollings Cancer Center, Medical University of South Carolina, Charleston, SC, United States; Department of Pathology and Laboratory Medicine, Medical University of South Carolina, Charleston, SC, United States., Turner DP; Hollings Cancer Center, Medical University of South Carolina, Charleston, SC, United States; Department of Pathology and Laboratory Medicine, Medical University of South Carolina, Charleston, SC, United States., Abraham LM; Department of Library Science and Informatics, Medical University of South Carolina, Charleston, SC, United States., Moore LA; College of Medicine, Medical University of South Carolina, Charleston, SC, United States., Magwood G; Hollings Cancer Center, Medical University of South Carolina, Charleston, SC, United States; College of Nursing, Medical University of South Carolina, Charleston, SC, United States., Alberg AJ; Department of Epidemiology and Biostatistics, University of South Carolina, Columbia, SC, United States., Gaymon K; College of Nursing, Medical University of South Carolina, Charleston, SC, United States., Knight KD; Professor, Department of Public Health Sciences, Medical University of South Carolina, Charleston, SC, United States., Hilton E; Department of Anesthesiology and Perioperative Medicine, Medical University of South Carolina, Charleston, SC, United States., Malek AM; Professor, Department of Public Health Sciences, Medical University of South Carolina, Charleston, SC, United States., Kramer RM; Department of Hematology/Oncology, Medical University of South Carolina, Charleston, SC, United States., Peterson LL; Department of Medicine, Washington University in St. Louis, St. Louis, MO, United States., Gregoski MJ; Department of Arts & Sciences, Campbell University, Buies Creek, NC, United States., Bolick S; South Carolina Department of Health and Environmental Control, Columbia, SC, United States., Hurley D; South Carolina Department of Health and Environmental Control, Columbia, SC, United States., Mosley C; South Carolina Department of Health and Environmental Control, Columbia, SC, United States., Hazelton TR; College of Nursing, Medical University of South Carolina, Charleston, SC, United States., Burshell DR; South Carolina Clinical & Translational Research Institute, Clinical and Translational Science Award, Medical University of South Carolina, Charleston, SC, United States., Nogueira L; Department of Pathology and Laboratory Medicine, Medical University of South Carolina, Charleston, SC, United States., Mack F; Chair, Department of Biological & Physical Sciences, South Carolina State University, Orangeburg, SC, United States., Brown ET; Morehouse School of Medicine, Atlanta, GA, United States., Salley JD; Chair, Department of Biological & Physical Sciences, South Carolina State University, Orangeburg, SC, United States., Whitfield KE; Provost and Senior Vice President for Academic Affairs, Wayne State University, Detroit, MI, United States., Esnaola NF; Professor of Surgery, Houston Methodist Academic Institute/Weill Cornell Medical College, Houston, TX, United States; Division Chief of Surgical Oncology and Gastrointestinal Surgery, Department of Surgery, Houston Methodist Hospital, Houston, TX, United States; Surgical Director and Associate Director of Community Engagement and Cancer Control, Houston Methodist Cancer Center, Houston, TX, United States; Katz Investigator, Houston Methodist Research Institute, Houston, TX, United States., Cunningham JE; The National Coalition of Independent Scholars, San Antonio, TX, United States.
Jazyk:	angličtina
Zdroj:	Advances in cancer research [Adv Cancer Res] 2020; Vol. 146, pp. 83-102. Date of Electronic Publication: 2020 Mar 12.
DOI:	10.1016/bs.acr.2020.01.005
Abstrakt:	Higher BMI, lower rates of physical activity (PA), and hormone receptor-negative breast cancer (BC) subtype are associated with poorer BC treatment outcomes. We evaluated the prevalence of high BMI, low PA level, and BC subtype among survivors with white/European American (EA) and African American (AA) ancestry, as well as a distinct subset of AAs with Sea Island/Gullah ancestry (SI). We used the South Carolina Central Cancer Registry to identify 137 (42 EAs, 66 AAs, and 29 SIs) women diagnosed with BC and who were within 6-21 months of diagnosis. We employed linear and logistic regression to investigate associations between BMI, PA, and age at diagnosis by racial/ethnic group. Most participants (82%) were overweight/obese (P=0.46). BMI was highest in younger AAs (P=0.02). CDC PA guidelines (≥150min/week) were met by only 28% of participants. The frequency of estrogen receptor (ER)-negative BC subtype was lower in EAs and SIs than in AAs (P<0.05). This is the first study to identify differences in obesity and PA rates, and BC subtype in EAs, AAs, and SIs. BMI was higher, PA rates were lower, and frequency of ER-negative BC was higher in AAs as compared to EAs and SIs. This study highlights the need to promote lifestyle interventions among BC survivors, with the goal of reducing the likelihood of a BC recurrence. Integrating dietary and PA interventions into ongoing survivorship care is essential. Future research could evaluate potential differential immune responses linked to the frequency of triple negative BC in AAs. (© 2020 Elsevier Inc. All rights reserved.)
Databáze:	MEDLINE
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